Category Archives: Neuroscience Abstracts

Overexpression of protrudin in primary cortical neurons enhances regeneration after laser axotomy through multiple mechanisms

Authors: V. PETROVA, R.EVA, J.W. FAWCETT Lab Abstract: Numerous extracellular and intracellular processes contribute to the failure of long-range regeneration in the adult central nervous system (CNS) after injury. One reason why adult CNS axons have poor regenerative capabilities is … Continue reading

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Lin28 protein regulates CNS axon regeneration in adult mammalians

Authors: Shuxin LI, F.NATHAN, Y.OHTAKE, H.GUO, A.SAMI Lab Abstract: Severed CNS axons fail to regenerate in adult mammals and there are no effective regenerative strategies to treat patients with CNS injuries. Several genes, including PTEN and Krüppel-like factors, regulate intrinsic … Continue reading

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Elevated phosphoinositide 3-kinase activity promotes axon regeneration of central nervous system neurons

Authors: B. NIEUWENHUIS, R.EVANS, C.S. PEARSON, A.C. BARBER, J. CAVE, P.D. SMITH, J. FUCHS, B.J. EICKHOLT, H.M. GELLER, K.R. MARTIN, R. EVA, J.W. FAWCETT Lab Abstract: Injury to the central nervous system (CNS) has severe consequences because adult CNS axons … Continue reading

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Identifying the most effective types of integration-free human iPS cell-derived neural stem/progenitor cells in the treatment of spinal cord injury

Identifying the most effective types of integration-free human iPS cell-derived neural stem/progenitor cells in the treatment of spinal cord injury Authors: T. IIDA, N. NAGOSHI, J. KOHYAMA, O. TSUJI, M. MATSUMOTO, M. NAKAMURA, H. OKANO Lab Abstract: INTRODUCTION: We have … Continue reading

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Alterations in spinal cord injury-induced plasticity of spinal rhythm generating interneurons following treadmill training with epidural stimulation in mouse

Authors: D. GARCIA-RAMIREZ, N. HA, L. YAO, K. A. SCHMIDT, S. F. GISZTER, K. J. DOUGHERTY Lab Abstract: “Neuronal circuitry generating locomotion is located in the thoracolumbar spinal cord. Spinal rhythm generating interneurons (INs) convert descending inputs into rhythmic outputs. … Continue reading

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Three prong approach bridges complete SCI in rodents

EPFL (Ecole polytechnique fédérale de Lausanne) in Switzerland and UCLA (University of California in Los Angeles, California) have collaborated in making severed nerve fibers  regenerate across a complete SCI to form a bridge in rodents.  Their three part recipe for … Continue reading

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An informative CSPG article out of Robarts Research Institute

One of the important strategies that labs have been focusing on for spinal cord injury has been how to best deal with CSPG (chondroitin sulfate proteoglycans) commonly known as the scar that builds up at the site of injury (lesion) … Continue reading

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More concept developments reported from the Courtine lab in Nature

For those following SCI research in the electrical stimulation field, this open access article in Nature Communications is worth a read.  Here, the Gregoire Courtine lab describes the concept and project where brain-controlled modulation coupled with constant stimulation during gait … Continue reading

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Spinal Cord Injury: Is the vagus nerve our neural connectome?

Read the Full Article at eLife Sciences The vagus nerve reports on the state of many of the organs in our body, including the heart, the lungs and the gut, and it relays this information to various neural control networks … Continue reading

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In a Break with Dogma, Myelin Boosts Neuron Growth in Spinal Cord Injuries

The molecule inhibits adult axon regeneration, but appears to stimulate young neurons by Scott LaFee Recovery after severe spinal cord injury is notoriously fraught, with permanent paralysis often the result. In recent years, researchers have increasingly turned to stem cell-based … Continue reading

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