Category Archives: Neuroscience Abstracts

In a Break with Dogma, Myelin Boosts Neuron Growth in Spinal Cord Injuries

The molecule inhibits adult axon regeneration, but appears to stimulate young neurons by Scott LaFee Recovery after severe spinal cord injury is notoriously fraught, with permanent paralysis often the result. In recent years, researchers have increasingly turned to stem cell-based … Continue reading

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A new microtubule-based approach for augmenting nerve regeneration

Most studies on microtubules in the nervous system have focused on the dynamic properties of the microtubules, with stabilization by taxol and related drugs being proposed as a therapeutic for nerve injury. However, while initial indications were hopeful, more recent … Continue reading

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Modulation of Receptor Protein Tyrosine Phosphatase Sigma Increases Chondroitin Sulfate Proteoglycan Degradation through Cathepsin B Secretion to Enhance Axon Outgrowth

Authors: Amanda Phuong Tran, Sapna Sundar, Meigen Yu, Bradley T. Lang and Jerry Silver Abstract: Severed axon tips reform growth cones following spinal cord injury that fail to regenerate, in part, because they become embedded within an inhibitory extracellular matrix. … Continue reading

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Task specific spinal cord epidural stimulation enables independent step cycles during BWST stepping in motor complete humans

Various studies in the animal model have shown recovery of stepping with spinal cord epidural stimulation following a spinal cord injury. Our group had shown that epidural stimulation of lumbosacral spinal cord, combined with activity based training, enabled four motor … Continue reading

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Neurons Survive Long-Term in Pigs with Spinal Cord Injuries

A major hurdle to using neural stem cells derived from genetically different donors to replace damaged or destroyed tissues, such as in a spinal cord injury, has been the persistent rejection of the introduced material (cells), necessitating the use of … Continue reading

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Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord.

Journal of Neural Engineering Abstract: OBJECTIVE: We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below … Continue reading

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Synaptic connectivity between host and neural progenitor cell-derived neurons after spinal cord injury

Neural stem cells (NSCs) grafted into sites of spinal cord injury (SCI) may act as new electrophysiological relays between host neurons above and below the lesion. Host axons regenerate robustly into NSC grafts and form synapses; in turn, graft axons … Continue reading

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A computational model of epidural electrical stimulation of the cervical spinal cord in non-human primates

Abstract: Cervical spinal cord injury alters the communication between the brain and the spinal circuits controlling movement, often leading to tetraplegia. Epidural Electrical Stimulation (EES) of the lumbar spinal cord has shown promising results to restore leg motor control after … Continue reading

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Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

Abstract: Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement. Failure of these projections to reorganize leads to permanent paralysis. Here we modeled these injuries in rodents. A severe contusion abolished all motor cortex … Continue reading

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Serotonin receptor and dendritic plasticity in the spinal cord mediated by chronic serotonergic pharmacotherapy combined with exercise following complete SCI in the adult rat

Abstract: Severe spinal cord injury (SCI) damages descending motor and serotonin (5-HT) fiber projections leading to paralysis and serotonin depletion. 5-HT receptors (5-HTRs) subsequently upregulate following 5-HT fiber degeneration, and dendritic density decreases indicative of atrophy. 5-HT pharmacotherapy or exercise can improve locomotor behavior after … Continue reading

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