Category Archives: Neuroscience Abstracts

Noradrenergic pathways and epidural electrical stimulation synergistically modulate proprioceptive feedback circuits in order to restore locomotion after SCI

Abstract Several interventions exploiting chemical and electrical neuromodulation therapies have been designed to engage spinal sensorimotor circuits in order to facilitate the recovery of standing and walking after spinal cord injury. However, the mechanisms through which electrical and chemical stimulation … Continue reading

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Assessment of the combined effects of chondroitinase and autologous Schwann cells on hand function after cervical SCI in primates

Abstract Introduction: Chondroitinase ABC and Schwann cells have been shown independently to promote functional recovery in rodents after contusive injury. Autologous human Schwann cells ahSC are being tested in Phase 1 clinical trials for sub-acute and chronic SCI. Recognizing the … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, Rehabilitation, Spinal Research, Stem Cell Research

Selective late I-wave stimulation enhances voluntary motor output after SCI

Abstract Targeted stimulation of the corticospinal tract has been shown to improve voluntary motor output in humans with spinal cord injury (SCI; Bunday and Perez, 2012). Here, we used a novel protocol that targeted late synaptic inputs into corticospinal neurons … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Rehabilitation, Spinal Research

Improvements in bladder, bowel and sexual outcomes following task specific training in human SCI

Abstract The loss of urogenital and bowel functions are some of the most important sequalae as a result of spinal cord injury (SCI). In an upper motor neuron (UMN) injury, a neurogenic bladder may manifest as a failure to store, … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Rehabilitation, Spinal Research

Comparative transcriptomic analysis of sprouting and regenerating corticospinal neurons

Abstract The corticospinal tract (CST) is a critical motor system in humans for voluntary movement. The inability of adult corticospinal axons to spontaneously regenerate after spinal cord injury (SCI) may be attributable in part to incomplete activation of neuronal growth … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, Spinal Research

LPA pathway modulates intrinsic axon growth of intact CNS neurons after spinal cord injury

Abstract Neurons in the adult central nervous system (CNS) are unable to regenerate after spinal cord injury (SCI) due to an inhibitory environment and a decreased intrinsic growth capacity. Modulating environmental inhibitors and their neuronal receptors such as Nogo Receptor … Continue reading

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Short and long term effects of neural progenitor transplantation following cervical spinal cord contusion injury

Video and Abstract: Impaired breathing is a devastating consequence of cervical spinal cord injury (SCI) that increases morbidity and the risk of mortality. Injuries at high-to-mid cervical levels (C1-4) result in the most severe deficits as the phrenic motor circuitry … Continue reading

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Extracellular vimentin

Abstract: We previously developed a novel compound, Denosomin, exhibited axonal growth activity in cultured neurons. Denosomin administration to contusive spinal cord-injured (SCI) mice, p.o., showed significant improvement of motor dysfunction. At the injured area, Denosomin increased the number of vimentin-expressing … Continue reading

Posted in Neuroscience Abstracts

Spinal Cord Mechanism for Ejaculation Identified by French Team

Researchers have identified a specialized area of neurons in the spinal cord that coordinate ejaculation, raising the possibility that electrical or pharmacologic interventions to stimulate this area could be used to help the process occur. The French scientists pioneering the … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Spinal Research

Locomotor-respiratory coupling after SCI and the effects of locomotor rehabilitation

Abstract: Background: Temporal coupling of respiratory and locomotor patterns may provide a neuromechanical advantage to breathing. Following incomplete spinal cord injury (ISCI), supraspinal input to spinal motoneurons is disrupted. Propriospinal pathways, however, often remain intact after ISCI and respiration and … Continue reading

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