Category Archives: Neuroscience Abstracts

Discovery Offers New Hope to Repair Spinal Cord Injuries

By Dana G. Smith, PhD / Gladstone News / April 24, 2017 Scientists at the Gladstone Institutes created a special type of neuron from human stem cells that could potentially repair spinal cord injuries. These cells, called V2a interneurons, transmit … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, Spinal Research, Stem Cell Research | Tagged , , , | 2 Comments

Robotic platform maximizing gravity-dependent gait interactions to train standing and walking after neurological disorders

Gait recovery after neurological disorders requires re-mastering the interplay between body mechanics and gravitational forces. Despite the importance of gravity-dependent gait interactions for promoting this learning, this essential aspect of gait rehabilitation have received little attention. Here, we introduce a … Continue reading

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Gait rehabilitation enabled by epidural electrical stimulation of lumbar segments in a person with a chronic incomplete SCI

Various studies in animal models showed that robot-assisted gait rehabilitation enabled by epidural electrical stimulation of the lumbar spinal cord improves the recovery of leg motor control after spinal cord injury. Recent studies showed that this stimulation is also capable … Continue reading

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Rerouting cortical drive through residual spinal tissue mediates motor function recovery after severe SCI

A severe contusion of thoracic segments disrupts the motor-circuit communication matrix linking the brain and the spinal cord. Electrochemical stimulation applied over lumbar segments restored this communication, which enabled volitional control of leg movements in rodents and humans with motor … Continue reading

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Noradrenergic pathways and epidural electrical stimulation synergistically modulate proprioceptive feedback circuits in order to restore locomotion after SCI

Abstract Several interventions exploiting chemical and electrical neuromodulation therapies have been designed to engage spinal sensorimotor circuits in order to facilitate the recovery of standing and walking after spinal cord injury. However, the mechanisms through which electrical and chemical stimulation … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Rehabilitation, Spinal Research

Assessment of the combined effects of chondroitinase and autologous Schwann cells on hand function after cervical SCI in primates

Abstract Introduction: Chondroitinase ABC and Schwann cells have been shown independently to promote functional recovery in rodents after contusive injury. Autologous human Schwann cells ahSC are being tested in Phase 1 clinical trials for sub-acute and chronic SCI. Recognizing the … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, Rehabilitation, Spinal Research, Stem Cell Research

Selective late I-wave stimulation enhances voluntary motor output after SCI

Abstract Targeted stimulation of the corticospinal tract has been shown to improve voluntary motor output in humans with spinal cord injury (SCI; Bunday and Perez, 2012). Here, we used a novel protocol that targeted late synaptic inputs into corticospinal neurons … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Rehabilitation, Spinal Research

Improvements in bladder, bowel and sexual outcomes following task specific training in human SCI

Abstract The loss of urogenital and bowel functions are some of the most important sequalae as a result of spinal cord injury (SCI). In an upper motor neuron (UMN) injury, a neurogenic bladder may manifest as a failure to store, … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Rehabilitation, Spinal Research

Comparative transcriptomic analysis of sprouting and regenerating corticospinal neurons

Abstract The corticospinal tract (CST) is a critical motor system in humans for voluntary movement. The inability of adult corticospinal axons to spontaneously regenerate after spinal cord injury (SCI) may be attributable in part to incomplete activation of neuronal growth … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, Spinal Research

LPA pathway modulates intrinsic axon growth of intact CNS neurons after spinal cord injury

Abstract Neurons in the adult central nervous system (CNS) are unable to regenerate after spinal cord injury (SCI) due to an inhibitory environment and a decreased intrinsic growth capacity. Modulating environmental inhibitors and their neuronal receptors such as Nogo Receptor … Continue reading

Posted in Neuroscience Abstracts, Spinal Research | 1 Comment