Category Archives: Neuroscience Abstracts

17th International Symposium on Neural Regeneration

The ISNR is a forum for the presentation and discussion of important research progress, insights and controversies important to advancing the understanding of injury responses and potential therapeutics targeting both peripheral nerve and central nervous system injuries. This year marks … Continue reading

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Nanoparticles limit damage in spinal cord injury

Injection after an injury reduces inflammation and scarring By Marla Paul After a spinal cord injury, a significant amount of secondary nerve damage is caused by inflammation and internal scarring that inhibits the ability of the nervous system to repair … Continue reading

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Regulateable Chondroitinase ABC gene therapy as a treatment for spinal cord injury

Following spinal cord injury the extracellular matrix undergoes significant remodeling. Scar formation is associated with upregulation of molecules known to be inhibitory to neural plasticity and recovery of function, including chondroitin sulphate proteoglycans (CSPGs). Enzymatic removal of CSPG glycosaminoglycan chains … Continue reading

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Combined expression of pro-regenerative transcription factors and transplanted stem cells to promote corticospinal tract regeneration.

The failure of axon regeneration in the injured spinal cord results in partial or complete loss of function distal to the injury. To restore the function, severed axons must regrow and functionally reconnect to appropriate targets below the injury site. … Continue reading

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A potent anti-spastic effect after intrathecal NK1 antisense oligonucleotide or subpial AAV9-NK1-ShRNA delivery in rats with chronic spinal transection-induced muscle spasticity

BACKGROUND: The spinal NK1 receptor system has been demonstrated to play an important role in the development and maintenance of chronic pain states after peripheral nerve injury. In contrast, its role in the development of spinal hyper-reflexia and muscle spasticity … Continue reading

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Spinal cord injury: Using cortical targets to improve motor function

A main goal of rehabilitation strategies in humans with SCI is to strengthen transmission in spared neural networks. Although neuromodulatory strategies have targeted different sites within the central nervous system to restore motor function following SCI, the role of cortical … Continue reading

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Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin–N-cadherin pathway after SCI

Central nervous system (CNS) injury transforms naive astrocytes into reactive astrocytes, which eventually become scar-forming astrocytes that can impair axonal regeneration and functional recovery. This sequential phenotypic change, known as reactive astrogliosis, has long been considered unidirectional and irreversible. However, … Continue reading

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Induction of immune tolerance by short-course immunosuppresion after spinal grafting of allogeneic neural precursors in pigs with previous chronic spinal cord traumatic injury.

Current clinical protocols use transient or continuous immunosuppression in patients receiving allogeneic neural precursor grafts for treatment of a variety of neurological diseases, including spinal trauma, stroke or ALS. At present there is no solid evidence, however, that would confirm … Continue reading

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Promoting targeted reinnervation of phrenic motor neurons and restoration of respiratory function using BDNF after SCI

We are working a novel approach to promote regrowth of damaged descending bulbospinal respiratory axons and reinnervation of their correct phrenic motor neuron (PhMN) targets after cervical spinal cord injury (SCI). Cervical SCI, which occurs in more than half of all … Continue reading

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New Pathways for Recovery of Function Following Paralysis

We are dedicated to developing disease and injury specific devices to help restore optimal physiology function in individuals suffering with paralysis due to injury and illness. We accomplish this by enabling the reactivation of damaged and dormant neural circuits through … Continue reading

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