Category Archives: Neuroscience Abstracts

Combined expression of pro-regenerative transcription factors and transplanted stem cells to promote corticospinal tract regeneration.

The failure of axon regeneration in the injured spinal cord results in partial or complete loss of function distal to the injury. To restore the function, severed axons must regrow and functionally reconnect to appropriate targets below the injury site. … Continue reading

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A potent anti-spastic effect after intrathecal NK1 antisense oligonucleotide or subpial AAV9-NK1-ShRNA delivery in rats with chronic spinal transection-induced muscle spasticity

BACKGROUND: The spinal NK1 receptor system has been demonstrated to play an important role in the development and maintenance of chronic pain states after peripheral nerve injury. In contrast, its role in the development of spinal hyper-reflexia and muscle spasticity … Continue reading

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Spinal cord injury: Using cortical targets to improve motor function

A main goal of rehabilitation strategies in humans with SCI is to strengthen transmission in spared neural networks. Although neuromodulatory strategies have targeted different sites within the central nervous system to restore motor function following SCI, the role of cortical … Continue reading

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Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin–N-cadherin pathway after SCI

Central nervous system (CNS) injury transforms naive astrocytes into reactive astrocytes, which eventually become scar-forming astrocytes that can impair axonal regeneration and functional recovery. This sequential phenotypic change, known as reactive astrogliosis, has long been considered unidirectional and irreversible. However, … Continue reading

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Induction of immune tolerance by short-course immunosuppresion after spinal grafting of allogeneic neural precursors in pigs with previous chronic spinal cord traumatic injury.

Current clinical protocols use transient or continuous immunosuppression in patients receiving allogeneic neural precursor grafts for treatment of a variety of neurological diseases, including spinal trauma, stroke or ALS. At present there is no solid evidence, however, that would confirm … Continue reading

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Promoting targeted reinnervation of phrenic motor neurons and restoration of respiratory function using BDNF after SCI

We are working a novel approach to promote regrowth of damaged descending bulbospinal respiratory axons and reinnervation of their correct phrenic motor neuron (PhMN) targets after cervical spinal cord injury (SCI). Cervical SCI, which occurs in more than half of all … Continue reading

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New Pathways for Recovery of Function Following Paralysis

We are dedicated to developing disease and injury specific devices to help restore optimal physiology function in individuals suffering with paralysis due to injury and illness. We accomplish this by enabling the reactivation of damaged and dormant neural circuits through … Continue reading

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The Impact of combination biologics on treadmill quadrupedal locomotion after spinal cord hemi-contusion in non-human primates

Introduction. Non-human primates can be trained to ambulate on a treadmill. Cervical contusions lead to both upper and lower extremity functional deficits. These can be analyzed in a coupled manner using kinematic tracking of forelimb and hindlimb joint cycles. We … Continue reading

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Oxygen improves blood flow, restores more function in spinal cord injuries

A new discovery at the University of Alberta will fundamentally alter how we view spinal cord function and rehabilitation after spinal cord injuries. Neuroscientists found that spinal blood flow in rats was unexpectedly compromised long after a spinal cord injury … Continue reading

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Discovery Offers New Hope to Repair Spinal Cord Injuries

By Dana G. Smith, PhD / Gladstone News / April 24, 2017 Scientists at the Gladstone Institutes created a special type of neuron from human stem cells that could potentially repair spinal cord injuries. These cells, called V2a interneurons, transmit … Continue reading

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