Category Archives: Neuroscience Abstracts

Therapeutic impact of grafted oligogenic-directly reprogrammed neural precursor cells and chondroitinase ABC for chronic spinal cord injury

Authors *S. NORI1, J.-E. AHLFORS2, M. KHAZAEI1, Y. LIU1, J. WANG1, T. FUEHRMANN3, M. M. PAKULSKA3, M. HETTIARATCHI3, P. POON3, M. S. SHOICHET3, M. G. FEHLINGS1,4; 1Div. of Genet. and Develop., Krembil Res. Inst., Toronto, ON, Canada; 2New World Labs., … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, Spinal Research, Stem Cell Research | Leave a comment

Novel induction of neural-ectoderm and differentiation of neural progenitors from human iPSCs using pressure

Authors: Z. PAPPALARDO1,2, L. CASSEREAU2, *B. A. ADAMS2, B. DOWNEY2, J. LIM2; 1San Francisco State Univ., San Francisco, CA; 2Xcell Biosci. Inc., San Francisco, CA Induced pluripotent stem cells (iPSCs) can be used for autologous regenerative medicine to treat conditions … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, Spinal Research, Stem Cell Research | Tagged , | 2 Comments

Differentiation and single cell RNA sequencing of V2a interneurons from human pluripotent stem cells

Authors *J. BUTTS1, D. A. MCCREEDY2, J. A. MARTINEZ-VARGAS3, C. A. GIFFORD4, L. J. NOBLE-HAEUSSLEIN5, T. C. MCDEVITT4; 1Bioengineering, Gladstone Inst. of Cardiovasc. Dis., San Francisco, CA; 2Neurolog. Surgery, UCSF, San Francisco, CA; 3Univ. of California – Berkeley, Berkeley, CA; … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, Spinal Research, Stem Cell Research | Tagged , | 1 Comment

Targeting improvements in bladder function with epidural stimulation after human SCI

Abstract Deficits in urological function after spinal cord injury (SCI) include neurogenic detrusor overactivity and uncoordinated bladder and external urethral sphincter contractions, resulting in inefficient emptying and high intravesical pressure. Urinary retention and an inability of the bladder to store … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Rehabilitation, Spinal Research | 2 Comments

Cellular mechanisms influencing corticospinal and sensory axonal regeneration into neural stem cell grafts after SCI

Abstract Injured corticospinal tract axons regenerate robustly into caudalized neural progenitor cell (NPC) grafts and form functional synaptic connections with graft-derived neurons. However, the developmental fate of grafted NPCs, and whether those differentiated graft-derived neural subtypes might influence the regeneration … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, Rehabilitation, Spinal Research, Stem Cell Research

Human neural stem cell grafts into non-human primate spinal cord contusion or hemisection lesions

Abstract We previously demonstrated that human neural stem cells (hNSCs) and multipotent neural progenitor cells (hNPCs) grafted into sites of rodent spinal cord injury (SCI) survive, extend axons, form synapses, support host axon regeneration, and improve functional recovery (Lu et … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, Spinal Research, Stem Cell Research | 1 Comment

17th International Symposium on Neural Regeneration

The ISNR is a forum for the presentation and discussion of important research progress, insights and controversies important to advancing the understanding of injury responses and potential therapeutics targeting both peripheral nerve and central nervous system injuries. This year marks … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Spinal Research | Tagged

Nanoparticles limit damage in spinal cord injury

Injection after an injury reduces inflammation and scarring By Marla Paul After a spinal cord injury, a significant amount of secondary nerve damage is caused by inflammation and internal scarring that inhibits the ability of the nervous system to repair … Continue reading

Posted in Neuroscience Abstracts, Regenerative Medicine, Spinal Research | Tagged ,

Regulateable Chondroitinase ABC gene therapy as a treatment for spinal cord injury

Following spinal cord injury the extracellular matrix undergoes significant remodeling. Scar formation is associated with upregulation of molecules known to be inhibitory to neural plasticity and recovery of function, including chondroitin sulphate proteoglycans (CSPGs). Enzymatic removal of CSPG glycosaminoglycan chains … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, Regenerative Medicine, Spinal Research, Stem Cell Research | Tagged

Combined expression of pro-regenerative transcription factors and transplanted stem cells to promote corticospinal tract regeneration.

The failure of axon regeneration in the injured spinal cord results in partial or complete loss of function distal to the injury. To restore the function, severed axons must regrow and functionally reconnect to appropriate targets below the injury site. … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, Regenerative Medicine, Spinal Research, Stem Cell Research | Tagged , ,