Category Archives: Neuroscience Abstracts

Three prong approach bridges complete SCI in rodents

EPFL (Ecole polytechnique fédérale de Lausanne) in Switzerland and UCLA (University of California in Los Angeles, California) have collaborated in making severed nerve fibers  regenerate across a complete SCI to form a bridge in rodents.  Their three part recipe for … Continue reading

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An informative CSPG article out of Robarts Research Institute

One of the important strategies that labs have been focusing on for spinal cord injury has been how to best deal with CSPG (chondroitin sulfate proteoglycans) commonly known as the scar that builds up at the site of injury (lesion) … Continue reading

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More concept developments reported from the Courtine lab in Nature

For those following SCI research in the electrical stimulation field, this open access article in Nature Communications is worth a read.  Here, the Gregoire Courtine lab describes the concept and project where brain-controlled modulation coupled with constant stimulation during gait … Continue reading

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Spinal Cord Injury: Is the vagus nerve our neural connectome?

Read the Full Article at eLife Sciences The vagus nerve reports on the state of many of the organs in our body, including the heart, the lungs and the gut, and it relays this information to various neural control networks … Continue reading

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In a Break with Dogma, Myelin Boosts Neuron Growth in Spinal Cord Injuries

The molecule inhibits adult axon regeneration, but appears to stimulate young neurons by Scott LaFee Recovery after severe spinal cord injury is notoriously fraught, with permanent paralysis often the result. In recent years, researchers have increasingly turned to stem cell-based … Continue reading

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A new microtubule-based approach for augmenting nerve regeneration

Most studies on microtubules in the nervous system have focused on the dynamic properties of the microtubules, with stabilization by taxol and related drugs being proposed as a therapeutic for nerve injury. However, while initial indications were hopeful, more recent … Continue reading

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Modulation of Receptor Protein Tyrosine Phosphatase Sigma Increases Chondroitin Sulfate Proteoglycan Degradation through Cathepsin B Secretion to Enhance Axon Outgrowth

Authors: Amanda Phuong Tran, Sapna Sundar, Meigen Yu, Bradley T. Lang and Jerry Silver Abstract: Severed axon tips reform growth cones following spinal cord injury that fail to regenerate, in part, because they become embedded within an inhibitory extracellular matrix. … Continue reading

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Task specific spinal cord epidural stimulation enables independent step cycles during BWST stepping in motor complete humans

Various studies in the animal model have shown recovery of stepping with spinal cord epidural stimulation following a spinal cord injury. Our group had shown that epidural stimulation of lumbosacral spinal cord, combined with activity based training, enabled four motor … Continue reading

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Neurons Survive Long-Term in Pigs with Spinal Cord Injuries

A major hurdle to using neural stem cells derived from genetically different donors to replace damaged or destroyed tissues, such as in a spinal cord injury, has been the persistent rejection of the introduced material (cells), necessitating the use of … Continue reading

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Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord.

Journal of Neural Engineering Abstract: OBJECTIVE: We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below … Continue reading

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