Category Archives: Chronic Spinal Cord Injury Research

Overexpression of protrudin in primary cortical neurons enhances regeneration after laser axotomy through multiple mechanisms

Authors: V. PETROVA, R.EVA, J.W. FAWCETT Lab Abstract: Numerous extracellular and intracellular processes contribute to the failure of long-range regeneration in the adult central nervous system (CNS) after injury. One reason why adult CNS axons have poor regenerative capabilities is … Continue reading

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Lin28 protein regulates CNS axon regeneration in adult mammalians

Authors: Shuxin LI, F.NATHAN, Y.OHTAKE, H.GUO, A.SAMI Lab Abstract: Severed CNS axons fail to regenerate in adult mammals and there are no effective regenerative strategies to treat patients with CNS injuries. Several genes, including PTEN and Krüppel-like factors, regulate intrinsic … Continue reading

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Case Western Reserve Researchers Restore Breathing and Partial Forelimb Function in Rats with Chronic Spinal Cord Injuries

Promising results provide hope for humans suffering from chronic paralysis “Millions of people worldwide are living with chronic spinal cord injuries, with 250,000 to 500,000 new cases each year—most from vehicle crashes or falls. The most severe spinal cord injuries … Continue reading

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Elevated phosphoinositide 3-kinase activity promotes axon regeneration of central nervous system neurons

Authors: B. NIEUWENHUIS, R.EVANS, C.S. PEARSON, A.C. BARBER, J. CAVE, P.D. SMITH, J. FUCHS, B.J. EICKHOLT, H.M. GELLER, K.R. MARTIN, R. EVA, J.W. FAWCETT Lab Abstract: Injury to the central nervous system (CNS) has severe consequences because adult CNS axons … Continue reading

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Identifying the most effective types of integration-free human iPS cell-derived neural stem/progenitor cells in the treatment of spinal cord injury

Identifying the most effective types of integration-free human iPS cell-derived neural stem/progenitor cells in the treatment of spinal cord injury Authors: T. IIDA, N. NAGOSHI, J. KOHYAMA, O. TSUJI, M. MATSUMOTO, M. NAKAMURA, H. OKANO Lab Abstract: INTRODUCTION: We have … Continue reading

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École Polytechnique Fédérale de Lausanne (EPFL) has implanted SCI trial patient walking 1/2 mile.

Spinal implant helps three paralysed men walk again By Pallab Ghosh Science correspondent, BBC News “Three paralysed men, who were told they would spend the rest of their lives in a wheelchair, are able to walk again thanks to doctors … Continue reading

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Nerve-on-a-Chip to Improve Functionality of Neuroprosthetic Devices

Read about the neuroprosthetic advancement at MEDGADGETS: “Scientists at the École Polytechnique Fédérale de Lausanne (EPFL) in Switzerland have created a special device to be able to stimulate and record signals from and to peripheral nerve fibers on a specialty … Continue reading

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Perspectives on “the biology of spinal cord regeneration success and failure”

Neural Regeneration Research Journal Authors: Philippa Mary Warren, Amanda Phuong Tran, and Jerry Silver, Ph.D. “In our recently co-authored Physiological Reviews manuscript entitled “The biology of regeneration failure and success after spinal cord injury” (Tran et al., 2018b), we sought … Continue reading

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Neuroplasticity after Spinal Cord Injury

Dr. Francisco Benavides from Miami Project explains the neuroplasticity experiments taking place at Miami Project.

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SCI Research and Rehabilitation: Mayo Clinic Radio

Dr. Kendall Lee, neurosurgeon and director of Mayo Clinic’s Neural Engineering Laboratories, covers two topics – deep brain stimulation surgery and the latest update on spinal cord injury research (at 10:00 min) from the neurosurgeon’s perspective. Rehabilitation for spinal cord … Continue reading

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