Category Archives: Chronic Spinal Cord Injury Research

Gene therapy reverses rat’s paralysis at King’s College London

Researchers at King’s have shown that rats with spinal cord injuries can re-learn skilled hand movements after being treated with a gene therapy that could be switched on and off using a common antibiotic. Researchers at King’s College London and … Continue reading

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Jan-Eric Ahlfors CEO and CSO of Fortuna Fix Presented at Unite to Cure

Jan-Eric Ahlfors, CEO and CSO of Fortuna, presented at the Fourth International Vatican Conference “Unite to Cure”. Fortuna’s directly reprogrammed cell technology platform was in a session entitled “The Pharmacy of the Future – Stem Cells and Cardiovascular, Pulmonary and … Continue reading

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Marquette professor awarded $1.6 million NIH grant for spinal cord injury research

Marquette University professor Murray Blackmore was awarded a $1.6 million grant from the National Institutes of Health to continue his research of spinal cord injury and paralysis. Dr. Murray Blackmore, associate professor of biomedical sciences in the College of Health … Continue reading

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Modulation of Receptor Protein Tyrosine Phosphatase Sigma Increases Chondroitin Sulfate Proteoglycan Degradation through Cathepsin B Secretion to Enhance Axon Outgrowth

Authors: Amanda Phuong Tran, Sapna Sundar, Meigen Yu, Bradley T. Lang and Jerry Silver Abstract: Severed axon tips reform growth cones following spinal cord injury that fail to regenerate, in part, because they become embedded within an inhibitory extracellular matrix. … Continue reading

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Translating promising strategies for bowel and bladder management in spinal cord injury

Loss of control over voiding following spinal cord injury (SCI) impacts autonomy, participation and dignity, and can cause life-threatening complications. The importance of SCI bowel and bladder dysfunction warrants significantly more attention from researchers in the field. To address this … Continue reading

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Task specific spinal cord epidural stimulation enables independent step cycles during BWST stepping in motor complete humans

Various studies in the animal model have shown recovery of stepping with spinal cord epidural stimulation following a spinal cord injury. Our group had shown that epidural stimulation of lumbosacral spinal cord, combined with activity based training, enabled four motor … Continue reading

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Neurons Survive Long-Term in Pigs with Spinal Cord Injuries

A major hurdle to using neural stem cells derived from genetically different donors to replace damaged or destroyed tissues, such as in a spinal cord injury, has been the persistent rejection of the introduced material (cells), necessitating the use of … Continue reading

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Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord.

Journal of Neural Engineering Abstract: OBJECTIVE: We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below … Continue reading

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Synaptic connectivity between host and neural progenitor cell-derived neurons after spinal cord injury

Neural stem cells (NSCs) grafted into sites of spinal cord injury (SCI) may act as new electrophysiological relays between host neurons above and below the lesion. Host axons regenerate robustly into NSC grafts and form synapses; in turn, graft axons … Continue reading

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The Role of Cortical Plasticity in Spinal Cord Injury Recovery – David Gimbel, MD

“The Role of Cortical Plasticity in Spinal Cord Injury Recovery” David Gimbel, MD Clinical Instructor University of Cincinnati College of Medicine

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