Category Archives: Stem Cell Research

An injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodeling

Nature Communications 8, Article number: 533 (2017) The cystic cavity that develops following injuries to brain or spinal cord is a major obstacle for tissue repair in central nervous system (CNS). Here we report that injection of imidazole-poly(organophosphazenes) (I-5), a … Continue reading

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It’s Not a Rat’s Race for Human Stem Cells Grafted to Repair Spinal Cord Injuries

By Scott LaFee Lengthy study finds that implanted neural stem cells grow slow and steady, and success needs to be measured accordingly More than one-and-a-half years after implantation, researchers at University of California San Diego School of Medicine and the … Continue reading

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InVivo Therapeutics restructures and suspends chronic SCI stem cell and gene therapy research programs

CAMBRIDGE, Mass. (August 28, 2017) – InVivo Therapeutics Holdings Corp. (NVIV) today announced that it is executing a strategic restructuring in order to focus on The INSPIRE Study: InVivo Study of Probable Benefit of the Neuro-Spinal Scaffold™ for Safety and … Continue reading

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Pretreatment May Unlock the Regenerative Potential of Neural Stem Cells in Chronic Spinal Cord Injury

Written by Kristin Della Volpe Michael G Fehlings, MD, PhD, spoke with Spine Universe about the study outcomes and potential clinical implications for patients with chronic spinal cord injury. Pretreatment with the bacterial enzyme Chondroitinase ABC (ChABC) improves the regenerative outcome … Continue reading

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Regulateable Chondroitinase ABC gene therapy as a treatment for spinal cord injury

Following spinal cord injury the extracellular matrix undergoes significant remodeling. Scar formation is associated with upregulation of molecules known to be inhibitory to neural plasticity and recovery of function, including chondroitin sulphate proteoglycans (CSPGs). Enzymatic removal of CSPG glycosaminoglycan chains … Continue reading

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Combined expression of pro-regenerative transcription factors and transplanted stem cells to promote corticospinal tract regeneration.

The failure of axon regeneration in the injured spinal cord results in partial or complete loss of function distal to the injury. To restore the function, severed axons must regrow and functionally reconnect to appropriate targets below the injury site. … Continue reading

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Overexpression of KLF6 in corticospinal tract neurons promotes axon growth after spinal injury

Axonal regeneration in the central nervous system is limited in part by a developmental decline in the intrinsic regenerative capacity of central nervous system (CNS) neurons. Changes in gene expression are likely involved, and thus transcription factors that orchestrate gene … Continue reading

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A potent anti-spastic effect after intrathecal NK1 antisense oligonucleotide or subpial AAV9-NK1-ShRNA delivery in rats with chronic spinal transection-induced muscle spasticity

BACKGROUND: The spinal NK1 receptor system has been demonstrated to play an important role in the development and maintenance of chronic pain states after peripheral nerve injury. In contrast, its role in the development of spinal hyper-reflexia and muscle spasticity … Continue reading

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Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin–N-cadherin pathway after SCI

Central nervous system (CNS) injury transforms naive astrocytes into reactive astrocytes, which eventually become scar-forming astrocytes that can impair axonal regeneration and functional recovery. This sequential phenotypic change, known as reactive astrogliosis, has long been considered unidirectional and irreversible. However, … Continue reading

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Patients with Complete Paralysis Show Additional Recovery of Arm, Hand and Finger Function at 9-months After Treatment with Asterias’ AST-OPC1

Third patient recovers two motor levels; three of six (50%) patients in AIS-A 10 million cell cohort have now recovered two motor levels on at least one side FREMONT, Calif., June 13, 2017 /PRNewswire/ –Asterias Biotherapeutics, Inc. (NYSE MKT: AST), … Continue reading

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