Category Archives: Stem Cell Research

Stroke Drug Boosts Stem Cell Therapy For Spinal Cord Injury In Rats

Posted on December 17, 2019 by christalpowell

Four months after treating them, Yasuhiro Shiga, MD, PhD, checked on his rats. Walking into the lab, he carried minimal expectations. Treating spinal cord injuries with stem cells had been tried by many people, many times before, with modest success … Continue reading →

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GDF10 promotes axonal regeneration and functional recovery: A novel gene therapy strategy for spinal cord injury

Posted on October 24, 2019 by christalpowell

Authors:*P. M. ABDUL-MUNEER, S. BHOWMICK, V. D’MELLO; Hackensack Meridian Hlth. JFK Med. Ctr., Edison, NJ Neuroscience 2019 LINK Lab Abstract: Spinal cord injury (SCI) occurs when there is damage from trauma, loss of normal blood supply, or a mass effect … Continue reading →

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, spinal cord injury research, Stem Cell Research | Tagged , , | 1 Comment

The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?

Posted on September 1, 2019 by christalpowell

Author: James W. Fawcett Abstract: Axon regeneration in the CNS is inhibited by many extrinsic and intrinsic factors. Because these act in parallel, no single intervention has been sufficient to enable full regeneration of damaged axons in the adult mammalian … Continue reading →

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Ligand, spinal cord injury research, Stem Cell Research | Tagged | Comments Off on The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?

The effects of a pro-angiogenic, RGD-functionalized, nanofiber composite biomaterial on mesenchymal stem cell-mediated repair of the injured spinal cord

Posted on June 30, 2019 by christalpowell

Abstract: Spinal cord injury (SCI) results in nervous tissue loss and so far untreatable functional impairments. Preclinical studies have demonstrated that a transplant of bone marrow-derived mesenchymal stem cells (MSCs) elicits paracrine effects resulting in anatomical repair and partial functional … Continue reading →

Posted in Biomaterials, Chronic Spinal Cord Injury Research, Neuroscience Abstracts, spinal cord injury research, Stem Cell Research | Tagged , , | Comments Off on The effects of a pro-angiogenic, RGD-functionalized, nanofiber composite biomaterial on mesenchymal stem cell-mediated repair of the injured spinal cord

Regeneration of Spinal Cord Connectivity Through Stem Cell Transplantation and Biomaterial Scaffolds

Posted on June 16, 2019 by christalpowell

Authors: Hiroyuki Katoh, Kazuya Yokota and Michael Fehlings “In this review, we outline the pathophysiology of SCI that makes the spinal cord refractory to regeneration and discuss the research that has been done with cell replacement and biomaterial implantation strategies, … Continue reading →

Posted in Biomaterials, Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged , , | 1 Comment

Putting 3D Printing to Work to Heal Spinal Cord Injury

Posted on June 9, 2019 by christalpowell

“For people whose spinal cords are injured in traffic accidents, sports mishaps, or other traumatic events, cell-based treatments have emerged as a potential avenue for encouraging healing. Now, taking advantage of advances in 3D printing technology, researchers have created customized … Continue reading →

Posted in Biomaterials, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged | 1 Comment

Opinion: Ethical Challenges in Using iPS Cells to Treat Paralysis

Posted on March 18, 2019 by christalpowell

Uncertainties about the cells’ risk profiles and the potential for hyping unproven therapies mean scientists and the media must tread carefully. On February 18, 2019, The Asahi Shimbun reported, “Ministry [of Health, Labor and Welfare in Japan] OKs 1st iPS [induced … Continue reading →

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Epigenetic regulation of axonal regeneration

Posted on February 17, 2019 by christalpowell

Authors: S. DI GIOVANNI, E. MACLACHLAN, I. PALMISANO, T. HUTSON, A. HERVERA, F. DE VIRGILIIS, M. DANZI, J. BIXBY, V. LEMMON Lab Abstract: Regeneration after peripheral nerve injury depends on the activation of key signalling events, the recruitment of transcription … Continue reading →

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged , | Comments Off on Epigenetic regulation of axonal regeneration

Transplanting Cells for Spinal Cord Repair: Who, What, When, Where and Why?

Posted on January 27, 2019 by christalpowell

Authors: L.V. Zholudeva, Michael.A. Lane Lab Abstract: “Cellular transplantation for repair of the injured spinal cord has a rich history with strategies focused on neuroprotection, immunomodulation, and neural reconstruction. The goal of the present review is to provide a concise … Continue reading →

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Stem Cell Therapy for Traumatic SCI

Posted on January 24, 2019 by christalpowell

In this presentation, Dr.Alicia Fuhrman in the Department of Rehabilitation Medicine, University of Washington, explains the complex and rapidly expanding field of stem cell medicine. She begins by clarifying what stem cells are and how they are used in different … Continue reading →

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