Category Archives: Stem Cell Research

Opinion: Ethical Challenges in Using iPS Cells to Treat Paralysis

Uncertainties about the cells’ risk profiles and the potential for hyping unproven therapies mean scientists and the media must tread carefully. On February 18, 2019, The Asahi Shimbun reported, “Ministry [of Health, Labor and Welfare in Japan] OKs 1st iPS [induced … Continue reading

Posted in Chronic Spinal Cord Injury Research, spinal cord injury research, Stem Cell Research | Leave a comment

Epigenetic regulation of axonal regeneration

Authors: S. DI GIOVANNI, E. MACLACHLAN, I. PALMISANO, T. HUTSON, A. HERVERA, F. DE VIRGILIIS, M. DANZI, J. BIXBY, V. LEMMON Lab Abstract: Regeneration after peripheral nerve injury depends on the activation of key signalling events, the recruitment of transcription … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged ,

Transplanting Cells for Spinal Cord Repair: Who, What, When, Where and Why?

Authors: L.V. Zholudeva, Michael.A. Lane Lab Abstract: “Cellular transplantation for repair of the injured spinal cord has a rich history with strategies focused on neuroprotection, immunomodulation, and neural reconstruction. The goal of the present review is to provide a concise … Continue reading

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Stem Cell Therapy for Traumatic SCI

In this presentation, Dr.Alicia Fuhrman in the Department of Rehabilitation Medicine, University of Washington, explains the complex and rapidly expanding field of stem cell medicine. She begins by clarifying what stem cells are and how they are used in different … Continue reading

Posted in Chronic Spinal Cord Injury Research, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged ,

Translational Regenerative Therapies for Chronic Spinal Cord Injury

Authors: Kyriakos Dalamagkas, Magdalini Tsintou, Amelia Seifalian, Alexander M. Seifalian Abstract: “Spinal cord injury is a chronic and debilitating neurological condition that is currently being managed symptomatically with no real therapeutic strategies available. Even though there is no consensus on the best time … Continue reading

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Biomimetic 3D-printed scaffolds for spinal cord injury repair

Authors: Jacob Koffler, Wei Zhu, Xin Qu, Oleksandr Platoshyn, Jennifer N. Dulin, John Brock, Lori Graham, Paul Lu, Jeff Sakamoto, Martin Marsala, Shaochen Chen, Mark H. Tuszynski “Current methods for bioprinting functional tissue lack appropriate biofabrication techniques to build complex 3D micro architectures essential for guiding cell … Continue reading

Posted in Biomaterials, Chronic Spinal Cord Injury Research, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged , , , , , , , , , , , | 2 Comments

Calcium imaging of synaptic connectivity between host and neural progenitor cell graft-derived neurons after spinal cord injury

Authors: STEVEN L. CETO, K. SEKIGUCHI, A. NIMMERJAHN, M. H. TUSZYNSKI; Lab Abstract: Neural stem cells (NSCs) grafted into sites of spinal cord injury (SCI) may act as new electrophysiological relays between host neurons above and below the lesion. Host … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged ,

Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury

Authors: Satoshi Nori, Mohamad Kahazaei, Christopher S. Ahuja, Kazuya Yokota, Jan-Eric Ahlfors, Yang Liu, Jain Wang, Shinsuke Shibata, Jonathon Chio, Marian H Hettiaratchi, Tobias Fuhrmann, Molly S. Shoichet, Michael G. Gehlings Summary: “Treatment of chronic spinal cord injury (SCI) is … Continue reading

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Inhibition of miR-383 promotes axon regeneration following injury

Authors: C. JUZWIK, B. MORQUETTE, Y. ZHANG, E. GOWING, C. BOUDREAU-PINSONNEAULT, V. VANGOOR, R. PASTERKAMP, C. MOORE, A. BAR-OR, A. E. FOURNIER Lab Abstract: Neuroinflammation can positively influence axon regeneration following injury in the central nervous system (CNS) but the … Continue reading

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Continued development of human neural stem cell grafts into non-human primate spinal cord contusion or hemisection lesions

Authors: *E. S. ROSENZWEIG, J. H. BROCK, P. LU, H. KUMAMARU, J. L. WEBER, C. A. WEINHOLTZ, R. MOSEANKO, S. HAWBECKER, R. PENDER, C. L. CRUZEN, E. A. SALEGIO,, J. HUIE, C. ALMEIDA, Y. S. NOUT-LOMAS, L. A. HAVTON, A. … Continue reading

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