Category Archives: Stem Cell Research

In a Break with Dogma, Myelin Boosts Neuron Growth in Spinal Cord Injuries

The molecule inhibits adult axon regeneration, but appears to stimulate young neurons by Scott LaFee Recovery after severe spinal cord injury is notoriously fraught, with permanent paralysis often the result. In recent years, researchers have increasingly turned to stem cell-based … Continue reading

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Jan-Eric Ahlfors CEO and CSO of Fortuna Fix Presented at Unite to Cure

Jan-Eric Ahlfors, CEO and CSO of Fortuna, presented at the Fourth International Vatican Conference “Unite to Cure”. Fortuna’s directly reprogrammed cell technology platform was in a session entitled “The Pharmacy of the Future – Stem Cells and Cardiovascular, Pulmonary and … Continue reading

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Marquette professor awarded $1.6 million NIH grant for spinal cord injury research

Marquette University professor Murray Blackmore was awarded a $1.6 million grant from the National Institutes of Health to continue his research of spinal cord injury and paralysis. Dr. Murray Blackmore, associate professor of biomedical sciences in the College of Health … Continue reading

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Neurons Survive Long-Term in Pigs with Spinal Cord Injuries

A major hurdle to using neural stem cells derived from genetically different donors to replace damaged or destroyed tissues, such as in a spinal cord injury, has been the persistent rejection of the introduced material (cells), necessitating the use of … Continue reading

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Synaptic connectivity between host and neural progenitor cell-derived neurons after spinal cord injury

Neural stem cells (NSCs) grafted into sites of spinal cord injury (SCI) may act as new electrophysiological relays between host neurons above and below the lesion. Host axons regenerate robustly into NSC grafts and form synapses; in turn, graft axons … Continue reading

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Alliance for Regenerative Medicine (ARM) Neuralstem Presentation

Alliance for Regenerative Medicine (ARM) Neuralstem Presentation April 17, 2018 Neuralstem is a clinical-stage biopharmaceutical company developing novel treatments for nervous system diseases of high unmet medical need. The company’s lead asset and stem cell therapy candidate, NSI-566, is a … Continue reading

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Gene jumpstarts regeneration of damaged nerve cells

For Yale University by Bill Hathaway Searching the entire genome, a Yale research team has identified a gene that when eliminated can spur regeneration of axons in nerve cells severed by spinal cord injury. “For the first time, the limits … Continue reading

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UCLA researchers find a way to repair nerve damage with stem cells

UCLA researchers have developed a way to use stem cells to help potentially rebuild damaged spinal cords. In a study published in January, researchers in the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research established a way … Continue reading

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Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury

Inhibitory chondroitin sulfate proteoglycans (CSPGs) in the extracellular matrix hinder axonal regeneration after spinal cord injury (SCI). In particular, CSPGs form ‘peri-neuronal nets’ that may limit axonal regrowth and synaptic plasticity. Moreover, CSPGs are newly synthesized at sites of central … Continue reading

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Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury

CNS injury often severs axons. Scar tissue that forms locally at the lesion site is thought to block axonal regeneration, resulting in permanent functional deficits. We report that inhibiting the generation of progeny by a subclass of pericytes led to … Continue reading

Posted in Chronic Spinal Cord Injury Research, Regenerative Medicine, Spinal Research, Stem Cell Research