Category Archives: Gene Therapy

The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?

Author: James W. Fawcett Abstract: Axon regeneration in the CNS is inhibited by many extrinsic and intrinsic factors. Because these act in parallel, no single intervention has been sufficient to enable full regeneration of damaged axons in the adult mammalian … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Ligand, spinal cord injury research, Stem Cell Research | Tagged

Regeneration of Spinal Cord Connectivity Through Stem Cell Transplantation and Biomaterial Scaffolds

Authors: Hiroyuki Katoh, Kazuya Yokota and Michael Fehlings “In this review, we outline the pathophysiology of SCI that makes the spinal cord refractory to regeneration and discuss the research that has been done with cell replacement and biomaterial implantation strategies, … Continue reading

Posted in Biomaterials, Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged , , | 1 Comment

Interfering with Semaphorin3A in perineuronal nets to enhance plasticity

Authors: D. CARULLI, R. BROERSEN, F. DE WINTER, H.-J. BOELE, B. HOBO, C. CANTO, E. M. MUIR, C. I. DE ZEEUW, J. VERHAAGEN Lab Abstract: Neuronal plasticity is crucial for our brain to learn, adapt to the environment and recover … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research | Tagged ,

Marquette receives $500,000 for research from the Bryon Riesch Foundation

The Bryon Riesch Paralysis Foundation pledged Feb. 15 to donate $500,000 to Marquette’s College of Health Sciences to fund research, particularly that of Murray Blackmore, an associate professor of biomedical sciences. Blackmore’s lab studies spinal cord injuries, but more specifically studies gene … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, spinal cord injury research | Tagged , ,

Epigenetic regulation of axonal regeneration

Authors: S. DI GIOVANNI, E. MACLACHLAN, I. PALMISANO, T. HUTSON, A. HERVERA, F. DE VIRGILIIS, M. DANZI, J. BIXBY, V. LEMMON Lab Abstract: Regeneration after peripheral nerve injury depends on the activation of key signalling events, the recruitment of transcription … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged ,

New strategy with small molecules found for potential complementary therapy to treat SCI

Read this Full Story at Science Digest HERE Most people with spinal cord injury are paralyzed from the injury site down, even when the cord isn’t completely severed. Why don’t the spared portions of the spinal cord keep working? Researchers … Continue reading

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Gene therapy reverses rat’s paralysis at King’s College London

Researchers at King’s have shown that rats with spinal cord injuries can re-learn skilled hand movements after being treated with a gene therapy that could be switched on and off using a common antibiotic. Researchers at King’s College London and … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, spinal cord injury research | Tagged , , | 1 Comment

Combined Gene Therapy and Stem Cell Transplantation for SCI

Dr. Murray Blackmore W2W 2017 Miami Research in the Blackmore Lab Neurons depend on long axons to communicate with target cells. Neurons in the brain and spinal cord have almost no ability to regenerate axons that are disrupted by injury … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, spinal cord injury research | Tagged | 3 Comments

Regulateable Chondroitinase ABC gene therapy as a treatment for spinal cord injury

Following spinal cord injury the extracellular matrix undergoes significant remodeling. Scar formation is associated with upregulation of molecules known to be inhibitory to neural plasticity and recovery of function, including chondroitin sulphate proteoglycans (CSPGs). Enzymatic removal of CSPG glycosaminoglycan chains … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged

Miracle chemical ‘cocktail’ could cure spinal cord damage

By Stephen Beech, SWNS A chemical “cocktail” could restore movement for people crippled after suffering spinal cord injuries, suggests new research. Scientists say the mixture of three molecules could potentially be given therapeutically to patients to aid in their recovery … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, spinal cord injury research | Tagged , , , | 2 Comments