Category Archives: Gene Therapy

An integrated in silico pipeline identifies a novel TF combination that promotes enhanced CST growth following injury

Posted on November 17, 2019 by christalpowell

Authors *I. VENKATESH1, Z. WANG2, V. MEHRA1, E. EASTWOOD1, M. SIMPSON1, A. CHAKRABORTY1, D. GROSS1, Z.BEINE1, M. CABAHUG1, G. OLSON1, M. G. BLACKMORE3;2Dept. of Biomed. Sci., 3Biomed. Sci., 1Marquette Univ., Milwaukee, WI Lab Abstract Embryonic and peripheral neurons respond to … Continue reading →

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, spinal cord injury research | Tagged , , | 1 Comment

GDF10 promotes axonal regeneration and functional recovery: A novel gene therapy strategy for spinal cord injury

Posted on October 24, 2019 by christalpowell

Authors:*P. M. ABDUL-MUNEER, S. BHOWMICK, V. D’MELLO; Hackensack Meridian Hlth. JFK Med. Ctr., Edison, NJ Neuroscience 2019 LINK Lab Abstract: Spinal cord injury (SCI) occurs when there is damage from trauma, loss of normal blood supply, or a mass effect … Continue reading →

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, spinal cord injury research, Stem Cell Research | Tagged , , | 1 Comment

The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?

Posted on September 1, 2019 by christalpowell

Author: James W. Fawcett Abstract: Axon regeneration in the CNS is inhibited by many extrinsic and intrinsic factors. Because these act in parallel, no single intervention has been sufficient to enable full regeneration of damaged axons in the adult mammalian … Continue reading →

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Ligand, spinal cord injury research, Stem Cell Research | Tagged | Comments Off on The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?

Regeneration of Spinal Cord Connectivity Through Stem Cell Transplantation and Biomaterial Scaffolds

Posted on June 16, 2019 by christalpowell

Authors: Hiroyuki Katoh, Kazuya Yokota and Michael Fehlings “In this review, we outline the pathophysiology of SCI that makes the spinal cord refractory to regeneration and discuss the research that has been done with cell replacement and biomaterial implantation strategies, … Continue reading →

Posted in Biomaterials, Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged , , | 1 Comment

Interfering with Semaphorin3A in perineuronal nets to enhance plasticity

Posted on June 2, 2019 by christalpowell

Authors: D. CARULLI, R. BROERSEN, F. DE WINTER, H.-J. BOELE, B. HOBO, C. CANTO, E. M. MUIR, C. I. DE ZEEUW, J. VERHAAGEN Lab Abstract: Neuronal plasticity is crucial for our brain to learn, adapt to the environment and recover … Continue reading →

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research | Tagged , | Comments Off on Interfering with Semaphorin3A in perineuronal nets to enhance plasticity

Marquette receives $500,000 for research from the Bryon Riesch Foundation

Posted on March 14, 2019 by christalpowell

The Bryon Riesch Paralysis Foundation pledged Feb. 15 to donate $500,000 to Marquette’s College of Health Sciences to fund research, particularly that of Murray Blackmore, an associate professor of biomedical sciences. Blackmore’s lab studies spinal cord injuries, but more specifically studies gene … Continue reading →

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Epigenetic regulation of axonal regeneration

Posted on February 17, 2019 by christalpowell

Authors: S. DI GIOVANNI, E. MACLACHLAN, I. PALMISANO, T. HUTSON, A. HERVERA, F. DE VIRGILIIS, M. DANZI, J. BIXBY, V. LEMMON Lab Abstract: Regeneration after peripheral nerve injury depends on the activation of key signalling events, the recruitment of transcription … Continue reading →

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged , | Comments Off on Epigenetic regulation of axonal regeneration

New strategy with small molecules found for potential complementary therapy to treat SCI

Posted on July 20, 2018 by christalpowell

Read this Full Story at Science Digest HERE Most people with spinal cord injury are paralyzed from the injury site down, even when the cord isn’t completely severed. Why don’t the spared portions of the spinal cord keep working? Researchers … Continue reading →

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Gene therapy reverses rat’s paralysis at King’s College London

Posted on June 15, 2018 by christalpowell

Researchers at King’s have shown that rats with spinal cord injuries can re-learn skilled hand movements after being treated with a gene therapy that could be switched on and off using a common antibiotic. Researchers at King’s College London and … Continue reading →

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, spinal cord injury research | Tagged , , | 1 Comment

Combined Gene Therapy and Stem Cell Transplantation for SCI

Posted on January 17, 2018 by christalpowell

Dr. Murray Blackmore W2W 2017 Miami Research in the Blackmore Lab Neurons depend on long axons to communicate with target cells. Neurons in the brain and spinal cord have almost no ability to regenerate axons that are disrupted by injury … Continue reading →

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, spinal cord injury research | Tagged | 3 Comments