Category Archives: Gene Therapy

Regulateable Chondroitinase ABC gene therapy as a treatment for spinal cord injury

Following spinal cord injury the extracellular matrix undergoes significant remodeling. Scar formation is associated with upregulation of molecules known to be inhibitory to neural plasticity and recovery of function, including chondroitin sulphate proteoglycans (CSPGs). Enzymatic removal of CSPG glycosaminoglycan chains … Continue reading

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Miracle chemical ‘cocktail’ could cure spinal cord damage

By Stephen Beech, SWNS A chemical “cocktail” could restore movement for people crippled after suffering spinal cord injuries, suggests new research. Scientists say the mixture of three molecules could potentially be given therapeutically to patients to aid in their recovery … Continue reading

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Combined expression of pro-regenerative transcription factors and transplanted stem cells to promote corticospinal tract regeneration.

The failure of axon regeneration in the injured spinal cord results in partial or complete loss of function distal to the injury. To restore the function, severed axons must regrow and functionally reconnect to appropriate targets below the injury site. … Continue reading

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Overexpression of KLF6 in corticospinal tract neurons promotes axon growth after spinal injury

Axonal regeneration in the central nervous system is limited in part by a developmental decline in the intrinsic regenerative capacity of central nervous system (CNS) neurons. Changes in gene expression are likely involved, and thus transcription factors that orchestrate gene … Continue reading

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Nerve growth At The Extremeties

Researchers have found a genetic signature located exclusively in the nerve cells that supply, or innervate, the muscles of an organism’s outermost extremities: the hands and feet. This signature, observed in both mice and chicks, involves the coordinated activity of … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, Spinal Research, Stem Cell Research

Protect Stem Cell Science from Stem Cell Quackery

FULL ARTICLE LINK: Genetic Engineering and Biotechnology News Keep the Opportunities, Lose the Opportunists Authors: Graham Parker, Ph.D. and Jeanne F. Loring, Ph.D. A recent article focused attention on the proliferation of unregulated clinics in the U.S. that promise stem … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, Spinal Research, Stem Cell Research | 2 Comments

Michael Lane – Breathing easier after spinal cord injury

From the Michael Lane Lab Website “With a primary focus on pre-clinical research, our long-term goal is to develop strategies for improving functional outcome after cervical spinal cord injury (SCI)” More than 20 years ago, a group of faculty members … Continue reading

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Jeffrey Petruska discusses research on axon growth mechanisms

Jeffrey Petruska, PhD, of the UofL Kentucky Spinal Cord Injury Research Center, describes his research of the mechanisms controlling adult axon growth. Dr. Petruska has received funding from KBRIN and collaborated with the KBRIN Bioinformatics team on this study. He … Continue reading

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Personalized Medicine for Rodents: What the Genomics Era can Teach Us in the Quest for Therapeutics

How the use of genomic information can inform treatments for patients, including the use of neural stem cells to generate axonal growth. Dr. Mark Tuszynski

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Could Cancer Genes Help Repair Spinal Cord Injuries?

A Marquette University researcher hopes his work could be a promising step towards a cure for spinal cord injuries. Dr. Murray Blackmore turned to an unlikely ally in his work – cancer genes. Current medical practices cannot heal a spinal … Continue reading

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