Category Archives: Regenerative Medicine

Repairing the Neural Highway by David Holmes in Nature Outline

by David Holmes Repairing the neural highway At present, there is no way to reverse damage to the spinal cord or to restore lost function. But regenerative therapies in the initial stages of clinical testing are offering hope. Nature Article: … Continue reading

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Therapeutic impact of grafted oligogenic-directly reprogrammed neural precursor cells and chondroitinase ABC for chronic spinal cord injury

Authors *S. NORI1, J.-E. AHLFORS2, M. KHAZAEI1, Y. LIU1, J. WANG1, T. FUEHRMANN3, M. M. PAKULSKA3, M. HETTIARATCHI3, P. POON3, M. S. SHOICHET3, M. G. FEHLINGS1,4; 1Div. of Genet. and Develop., Krembil Res. Inst., Toronto, ON, Canada; 2New World Labs., … Continue reading

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Long Term Neural Stem Cell Transplant to repair Spinal Cord Injury: neurogenesis, gliogenesis and axon persistence

Paul Lu, PhD, Associate Researcher, University of California, San Diego – School of Medicine My primary research focuses on gene therapy and neural stem cells for spinal cord injury. My early studies focus on ex vivo gene therapy with neurotrophic … Continue reading

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Molecular controls over corticospinal motor neuron segmental targeting

Authors: *V. V. SAHNI1, S. SHNIDER1, D. JABAUDON2, J. SONG1, F. DING1, J. D. MACKLIS1; 1Stem Cell and Regenerative Biol. and Ctr. for Brain Sci., Harvard Univ., Cambridge, MA; 2Univ. of Geneva, Geneva, Switzerland The corticospinal system controls performance of … Continue reading

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Novel induction of neural-ectoderm and differentiation of neural progenitors from human iPSCs using pressure

Authors: Z. PAPPALARDO1,2, L. CASSEREAU2, *B. A. ADAMS2, B. DOWNEY2, J. LIM2; 1San Francisco State Univ., San Francisco, CA; 2Xcell Biosci. Inc., San Francisco, CA Induced pluripotent stem cells (iPSCs) can be used for autologous regenerative medicine to treat conditions … Continue reading

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Differentiation and single cell RNA sequencing of V2a interneurons from human pluripotent stem cells

Authors *J. BUTTS1, D. A. MCCREEDY2, J. A. MARTINEZ-VARGAS3, C. A. GIFFORD4, L. J. NOBLE-HAEUSSLEIN5, T. C. MCDEVITT4; 1Bioengineering, Gladstone Inst. of Cardiovasc. Dis., San Francisco, CA; 2Neurolog. Surgery, UCSF, San Francisco, CA; 3Univ. of California – Berkeley, Berkeley, CA; … Continue reading

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Fortuna Fix Announces Series B Financing, Adding Amgen Ventures and Macnguyen Family Office as Shareholders

(Newswire.com) Press Release: November 8, 2017 Fortuna Fix – Fortuna Fix (“Fortuna”), a private, clinical-stage Regenerative Medicine company is aiming to be the first to bring to the clinic a patient’s own neural stem cells (autologous) produced by direct reprogramming … Continue reading

Posted in Biomaterials, Chronic Spinal Cord Injury Research, Regenerative Medicine, Spinal Research, Stem Cell Research | Tagged ,

Cellular mechanisms influencing corticospinal and sensory axonal regeneration into neural stem cell grafts after SCI

Abstract Injured corticospinal tract axons regenerate robustly into caudalized neural progenitor cell (NPC) grafts and form functional synaptic connections with graft-derived neurons. However, the developmental fate of grafted NPCs, and whether those differentiated graft-derived neural subtypes might influence the regeneration … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, Rehabilitation, Spinal Research, Stem Cell Research

Human neural stem cell grafts into non-human primate spinal cord contusion or hemisection lesions

Abstract We previously demonstrated that human neural stem cells (hNSCs) and multipotent neural progenitor cells (hNPCs) grafted into sites of rodent spinal cord injury (SCI) survive, extend axons, form synapses, support host axon regeneration, and improve functional recovery (Lu et … Continue reading

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Two Leading Spinal Cord Injury Experts Join ReNetX Scientific Advisory Board

NEW HAVEN, Conn., Oct. 10, 2017 (GLOBE NEWSWIRE) — ReNetX Bio, a company developing first-in-class therapeutics to treat injury to the central nervous system, is expanding its Scientific Advisory Board with key opinion leaders specializing in spinal cord injury. ReNetX … Continue reading

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