Category Archives: Regenerative Medicine

Neurons Survive Long-Term in Pigs with Spinal Cord Injuries

A major hurdle to using neural stem cells derived from genetically different donors to replace damaged or destroyed tissues, such as in a spinal cord injury, has been the persistent rejection of the introduced material (cells), necessitating the use of … Continue reading

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Synaptic connectivity between host and neural progenitor cell-derived neurons after spinal cord injury

Neural stem cells (NSCs) grafted into sites of spinal cord injury (SCI) may act as new electrophysiological relays between host neurons above and below the lesion. Host axons regenerate robustly into NSC grafts and form synapses; in turn, graft axons … Continue reading

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The Role of Cortical Plasticity in Spinal Cord Injury Recovery – David Gimbel, MD

“The Role of Cortical Plasticity in Spinal Cord Injury Recovery” David Gimbel, MD Clinical Instructor University of Cincinnati College of Medicine

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Alliance for Regenerative Medicine (ARM) Neuralstem Presentation

Alliance for Regenerative Medicine (ARM) Neuralstem Presentation April 17, 2018 Neuralstem is a clinical-stage biopharmaceutical company developing novel treatments for nervous system diseases of high unmet medical need. The company’s lead asset and stem cell therapy candidate, NSI-566, is a … Continue reading

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Serotonin receptor and dendritic plasticity in the spinal cord mediated by chronic serotonergic pharmacotherapy combined with exercise following complete SCI in the adult rat

Abstract: Severe spinal cord injury (SCI) damages descending motor and serotonin (5-HT) fiber projections leading to paralysis and serotonin depletion. 5-HT receptors (5-HTRs) subsequently upregulate following 5-HT fiber degeneration, and dendritic density decreases indicative of atrophy. 5-HT pharmacotherapy or exercise can improve locomotor behavior after … Continue reading

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Linking axon transport to regeneration using in vitro laser axotomy

Abstract: Spinal cord injury has devastating consequences because adult central nervous system (CNS) neurons do not regenerate their axons after injury. Two key reasons for axon regeneration failure are extrinsic inhibitory factors and a low intrinsic capacity for axon regrowth. … Continue reading

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Gene jumpstarts regeneration of damaged nerve cells

For Yale University by Bill Hathaway Searching the entire genome, a Yale research team has identified a gene that when eliminated can spur regeneration of axons in nerve cells severed by spinal cord injury. “For the first time, the limits … Continue reading

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UCLA researchers find a way to repair nerve damage with stem cells

UCLA researchers have developed a way to use stem cells to help potentially rebuild damaged spinal cords. In a study published in January, researchers in the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research established a way … Continue reading

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Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury

Inhibitory chondroitin sulfate proteoglycans (CSPGs) in the extracellular matrix hinder axonal regeneration after spinal cord injury (SCI). In particular, CSPGs form ‘peri-neuronal nets’ that may limit axonal regrowth and synaptic plasticity. Moreover, CSPGs are newly synthesized at sites of central … Continue reading

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Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury

CNS injury often severs axons. Scar tissue that forms locally at the lesion site is thought to block axonal regeneration, resulting in permanent functional deficits. We report that inhibiting the generation of progeny by a subclass of pericytes led to … Continue reading

Posted in Chronic Spinal Cord Injury Research, Regenerative Medicine, Spinal Research, Stem Cell Research