Category Archives: Regenerative Medicine

Translational Regenerative Therapies for Chronic Spinal Cord Injury

Authors: Kyriakos Dalamagkas, Magdalini Tsintou, Amelia Seifalian, Alexander M. Seifalian Abstract: “Spinal cord injury is a chronic and debilitating neurological condition that is currently being managed symptomatically with no real therapeutic strategies available. Even though there is no consensus on the best time … Continue reading

Posted in Chronic Spinal Cord Injury Research, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged , , , | 3 Comments

Biomimetic 3D-printed scaffolds for spinal cord injury repair

Authors: Jacob Koffler, Wei Zhu, Xin Qu, Oleksandr Platoshyn, Jennifer N. Dulin, John Brock, Lori Graham, Paul Lu, Jeff Sakamoto, Martin Marsala, Shaochen Chen, Mark H. Tuszynski “Current methods for bioprinting functional tissue lack appropriate biofabrication techniques to build complex 3D micro architectures essential for guiding cell … Continue reading

Posted in Biomaterials, Chronic Spinal Cord Injury Research, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged , , , , , , , , , , , | 2 Comments

Calcium imaging of synaptic connectivity between host and neural progenitor cell graft-derived neurons after spinal cord injury

Authors: STEVEN L. CETO, K. SEKIGUCHI, A. NIMMERJAHN, M. H. TUSZYNSKI; Lab Abstract: Neural stem cells (NSCs) grafted into sites of spinal cord injury (SCI) may act as new electrophysiological relays between host neurons above and below the lesion. Host … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged , | Leave a comment

Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury

Authors: Satoshi Nori, Mohamad Kahazaei, Christopher S. Ahuja, Kazuya Yokota, Jan-Eric Ahlfors, Yang Liu, Jain Wang, Shinsuke Shibata, Jonathon Chio, Marian H Hettiaratchi, Tobias Fuhrmann, Molly S. Shoichet, Michael G. Gehlings Summary: “Treatment of chronic spinal cord injury (SCI) is … Continue reading

Posted in Chronic Spinal Cord Injury Research, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged , , , , , , , , , , , , | 2 Comments

Inhibition of miR-383 promotes axon regeneration following injury

Authors: C. JUZWIK, B. MORQUETTE, Y. ZHANG, E. GOWING, C. BOUDREAU-PINSONNEAULT, V. VANGOOR, R. PASTERKAMP, C. MOORE, A. BAR-OR, A. E. FOURNIER Lab Abstract: Neuroinflammation can positively influence axon regeneration following injury in the central nervous system (CNS) but the … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged , , | Leave a comment

Continued development of human neural stem cell grafts into non-human primate spinal cord contusion or hemisection lesions

Authors: *E. S. ROSENZWEIG, J. H. BROCK, P. LU, H. KUMAMARU, J. L. WEBER, C. A. WEINHOLTZ, R. MOSEANKO, S. HAWBECKER, R. PENDER, C. L. CRUZEN, E. A. SALEGIO,, J. HUIE, C. ALMEIDA, Y. S. NOUT-LOMAS, L. A. HAVTON, A. … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged ,

Overexpression of protrudin in primary cortical neurons enhances regeneration after laser axotomy through multiple mechanisms

Authors: V. PETROVA, R.EVA, J.W. FAWCETT Lab Abstract: Numerous extracellular and intracellular processes contribute to the failure of long-range regeneration in the adult central nervous system (CNS) after injury. One reason why adult CNS axons have poor regenerative capabilities is … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged ,

Lin28 protein regulates CNS axon regeneration in adult mammalians

Authors: Shuxin LI, F.NATHAN, Y.OHTAKE, H.GUO, A.SAMI Lab Abstract: Severed CNS axons fail to regenerate in adult mammals and there are no effective regenerative strategies to treat patients with CNS injuries. Several genes, including PTEN and Krüppel-like factors, regulate intrinsic … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged , , , | 1 Comment

Case Western Reserve Researchers Restore Breathing and Partial Forelimb Function in Rats with Chronic Spinal Cord Injuries

Promising results provide hope for humans suffering from chronic paralysis “Millions of people worldwide are living with chronic spinal cord injuries, with 250,000 to 500,000 new cases each year—most from vehicle crashes or falls. The most severe spinal cord injuries … Continue reading

Posted in Chronic Spinal Cord Injury Research, Regenerative Medicine, spinal cord injury research | Tagged , ,

Elevated phosphoinositide 3-kinase activity promotes axon regeneration of central nervous system neurons

Authors: B. NIEUWENHUIS, R.EVANS, C.S. PEARSON, A.C. BARBER, J. CAVE, P.D. SMITH, J. FUCHS, B.J. EICKHOLT, H.M. GELLER, K.R. MARTIN, R. EVA, J.W. FAWCETT Lab Abstract: Injury to the central nervous system (CNS) has severe consequences because adult CNS axons … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged ,