Category Archives: Regenerative Medicine

Two Leading Spinal Cord Injury Experts Join ReNetX Scientific Advisory Board

NEW HAVEN, Conn., Oct. 10, 2017 (GLOBE NEWSWIRE) — ReNetX Bio, a company developing first-in-class therapeutics to treat injury to the central nervous system, is expanding its Scientific Advisory Board with key opinion leaders specializing in spinal cord injury. ReNetX … Continue reading

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Get registered for Working 2 Walk 2017 today!

Plan to join us in Miami for our 12th annual Working 2 Walk Symposium. The conference is a unique opportunity for spinal cord injury advocates, scientists, clinicians, and investors to meet and share the latest news & strategies, and form … Continue reading

Posted in Chronic Spinal Cord Injury Research, Regenerative Medicine, Spinal Research, Unite 2 Fight Paralysis, Working 2 Walk Science & Advocacy Symposium | 1 Comment

An injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodeling

Nature Communications 8, Article number: 533 (2017) The cystic cavity that develops following injuries to brain or spinal cord is a major obstacle for tissue repair in central nervous system (CNS). Here we report that injection of imidazole-poly(organophosphazenes) (I-5), a … Continue reading

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Nanoparticles limit damage in spinal cord injury

Injection after an injury reduces inflammation and scarring By Marla Paul After a spinal cord injury, a significant amount of secondary nerve damage is caused by inflammation and internal scarring that inhibits the ability of the nervous system to repair … Continue reading

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It’s Not a Rat’s Race for Human Stem Cells Grafted to Repair Spinal Cord Injuries

By Scott LaFee Lengthy study finds that implanted neural stem cells grow slow and steady, and success needs to be measured accordingly More than one-and-a-half years after implantation, researchers at University of California San Diego School of Medicine and the … Continue reading

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Pretreatment May Unlock the Regenerative Potential of Neural Stem Cells in Chronic Spinal Cord Injury

Written by Kristin Della Volpe Michael G Fehlings, MD, PhD, spoke with Spine Universe about the study outcomes and potential clinical implications for patients with chronic spinal cord injury. Pretreatment with the bacterial enzyme Chondroitinase ABC (ChABC) improves the regenerative outcome … Continue reading

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Regulateable Chondroitinase ABC gene therapy as a treatment for spinal cord injury

Following spinal cord injury the extracellular matrix undergoes significant remodeling. Scar formation is associated with upregulation of molecules known to be inhibitory to neural plasticity and recovery of function, including chondroitin sulphate proteoglycans (CSPGs). Enzymatic removal of CSPG glycosaminoglycan chains … Continue reading

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Miracle chemical ‘cocktail’ could cure spinal cord damage

By Stephen Beech, SWNS A chemical “cocktail” could restore movement for people crippled after suffering spinal cord injuries, suggests new research. Scientists say the mixture of three molecules could potentially be given therapeutically to patients to aid in their recovery … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, Spinal Research | Tagged , , , | 1 Comment

Combined expression of pro-regenerative transcription factors and transplanted stem cells to promote corticospinal tract regeneration.

The failure of axon regeneration in the injured spinal cord results in partial or complete loss of function distal to the injury. To restore the function, severed axons must regrow and functionally reconnect to appropriate targets below the injury site. … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, Regenerative Medicine, Spinal Research, Stem Cell Research | Tagged , ,

Structural and Functional Substitution of Deleted Primary Sensory Neurons by New Growth from Intrinsic Spinal Cord Nerve Cells: An Alternative Concept in Reconstruction of Spinal Cord Circuits

In a recent clinical report, return of the tendon stretch reflex was demonstrated after spinal cord surgery in a case of total traumatic brachial plexus avulsion injury. Peripheral nerve grafts had been implanted into the spinal cord to reconnect to … Continue reading

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