Authors: *S. LV1, W. WU2;
1 Guangdong-hongkong-Macau Inst. of CNS Regeneration, Guangzhou, China;
2 The Univ.Of Hong Kong, Hong Kong SAR, Hong Kong
Lab Abstract: Ventral root injury results in great loss of motor functions because of the inefficient axon regeneration and severe atrophy of target organ. PTEN act as a negative regulatory factor at PI3K/AKT pathway also inhibit the regeneration of axons. It has been shown that PTEN antagonist peptides(PAPs) can significantly stimulated growth of descending serotonergic fibers and sprouting of corticospinal fibers in the rostral spinal cord after spinal cord injury.
Here, we are reporting that after a spinal ventral root crush completely in adult rats, PAPs peptides treatment remarkably improved motor functional recovery. PAPs-treated animals showed less motoneuron death, increased the number of regenerated axons, rebuilt healthy neuromuscular junction and enhanced potentiated electrical responses of motor units. Our study showed that PAPs was a promising pharmacological method for promoting motor functional recovery after peripheral nerve injury.
Society for Neuroscience 2019
051. Axon Injury and Recovery
Location: Hall A
Time: Saturday, October 19, 2019, 1:00 PM – 5:00 PM
Program #/Poster #: 051.03/G33
Topic: C.11. Spinal Cord Injury and Plasticity