Author Archives: christalpowell

Spinal cord injury: Using cortical targets to improve motor function

A main goal of rehabilitation strategies in humans with SCI is to strengthen transmission in spared neural networks. Although neuromodulatory strategies have targeted different sites within the central nervous system to restore motor function following SCI, the role of cortical … Continue reading

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43 Disability Protesters outside of Senate Mitch McConnell’s office arrested over proposed severe Medicaid cuts.

LINK: The Senate Puts Medicaid on the Chopping Block A draft version of the AHCA released Thursday shows even deeper cuts to the program than the House version. The new AHCA is a lot like the old AHCA. After weeks … Continue reading

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Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin–N-cadherin pathway after SCI

Central nervous system (CNS) injury transforms naive astrocytes into reactive astrocytes, which eventually become scar-forming astrocytes that can impair axonal regeneration and functional recovery. This sequential phenotypic change, known as reactive astrogliosis, has long been considered unidirectional and irreversible. However, … Continue reading

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SCI Stem-cell pioneer enters the political field in California

Hans Keirstead, a pioneering stem-cell biologist and multimillionaire businessman who was a professor at UC Irvine for 14 years, announced Thursday he would join the field of Democrats challenging Rep. Dana Rohrabacher, R-Costa Mesa. Keirstead said the leading motivation for … Continue reading

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Patients with Complete Paralysis Show Additional Recovery of Arm, Hand and Finger Function at 9-months After Treatment with Asterias’ AST-OPC1

Third patient recovers two motor levels; three of six (50%) patients in AIS-A 10 million cell cohort have now recovered two motor levels on at least one side FREMONT, Calif., June 13, 2017 /PRNewswire/ –Asterias Biotherapeutics, Inc. (NYSE MKT: AST), … Continue reading

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Induction of immune tolerance by short-course immunosuppresion after spinal grafting of allogeneic neural precursors in pigs with previous chronic spinal cord traumatic injury.

Current clinical protocols use transient or continuous immunosuppression in patients receiving allogeneic neural precursor grafts for treatment of a variety of neurological diseases, including spinal trauma, stroke or ALS. At present there is no solid evidence, however, that would confirm … Continue reading

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Growth Hormone Improves Sensory Function in Complete Spinal Injury

Deficiency Growth Hormone and Spinal Cord Injury: In March 2013, the Spanish Medicines Agency approved a pilot clinical trial to investigate the efficacy of growth hormone (GH) as an adjunct to intensive rehabilitation in patients with spinal cord injury and … Continue reading

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Promoting targeted reinnervation of phrenic motor neurons and restoration of respiratory function using BDNF after SCI

We are working a novel approach to promote regrowth of damaged descending bulbospinal respiratory axons and reinnervation of their correct phrenic motor neuron (PhMN) targets after cervical spinal cord injury (SCI). Cervical SCI, which occurs in more than half of all … Continue reading

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New Pathways for Recovery of Function Following Paralysis

We are dedicated to developing disease and injury specific devices to help restore optimal physiology function in individuals suffering with paralysis due to injury and illness. We accomplish this by enabling the reactivation of damaged and dormant neural circuits through … Continue reading

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The Impact of combination biologics on treadmill quadrupedal locomotion after spinal cord hemi-contusion in non-human primates

Introduction. Non-human primates can be trained to ambulate on a treadmill. Cervical contusions lead to both upper and lower extremity functional deficits. These can be analyzed in a coupled manner using kinematic tracking of forelimb and hindlimb joint cycles. We … Continue reading

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