Category Archives: spinal cord injury research

Candidate Therapy From Quebec for Chronic SCI Being Developed in Parallel by Academics and Companies in Switzerland and the Netherlands

QUEBEC CITY, CANADA, October 10th 2019 – Today, Laboratoires Guertin announces that a campaign for funding has been launched to support a phase IIb-enabling pilot study with a tritherapy candidate (buspirone/L-DOPA/carbidopa)called Spinalon. This experimental oral pill has been shown to … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuromodulation, Rehabilitation, spinal cord injury research | Tagged | 4 Comments

Moving beyond the glial scar for spinal cord repair

Authors: Elizabeth J. Bradbury and Emily R. Burnside Abstract: Traumatic spinal cord injury results in severe and irreversible loss of function. The injury triggers a complex cascade of inflammatory and pathological processes, culminating in formation of a scar. While traditionally … Continue reading

Posted in Chronic Spinal Cord Injury Research, Regenerative Medicine, spinal cord injury research | Tagged , | 1 Comment

The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?

Author: James W. Fawcett Abstract: Axon regeneration in the CNS is inhibited by many extrinsic and intrinsic factors. Because these act in parallel, no single intervention has been sufficient to enable full regeneration of damaged axons in the adult mammalian … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Ligand, spinal cord injury research, Stem Cell Research | Tagged

The potential of electric field for promoting neurite guidance in spinal cord injury regeneration strategies

Authors*A. VARONE, Z. N. MUHAMAT, A. M. RAJNICEK, W. HUANG; Lab Abstract: Introduction Spinal cord injury, for which there is no cure, can lead to permanent loss of neurological function. Reasons for failed axon regrowth include poor intrinsic growth capacity … Continue reading

Posted in Chronic Spinal Cord Injury Research, spinal cord injury research | Tagged , , | 2 Comments

Extraction and selective activation of muscle synergies through spinal stimulation for SCI

Authors: *R. CHENG, J. W. BURDICK; Lab Abstract: Epidural spinal stimulation (ESS) has been shown to enable recovery of motor control in patients with clinically complete spinal cord injury (SCI). It is hypothesized that this results from activation of postural … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuromodulation, Neuroscience Abstracts, Rehabilitation, spinal cord injury research | Tagged , , | 2 Comments

Early limb unloading elicits long-term motor deficits involving motorneuron hyperexcitability associated with persistent alterations in glutamatergic synaptic plasticity in spinal cord injury

Authors: *K. MORIOKA1,2, T. TAZOE3,2, J. HUIE1,4, J. HAEFELI1, C. A. ALMEIDA1, J. A. SACRAMENTO1, J. C. BRESNAHAN1, M. S. BEATTIE1, S. TANAKA5, T. OGATA2, A. R. FERGUSON1,4; Lab Abstract: Abnormal sensory afferent feedback from the lower extremities after spinal … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuromodulation, Neuroscience Abstracts, spinal cord injury research | Tagged , ,

The effects of a pro-angiogenic, RGD-functionalized, nanofiber composite biomaterial on mesenchymal stem cell-mediated repair of the injured spinal cord

Abstract: Spinal cord injury (SCI) results in nervous tissue loss and so far untreatable functional impairments. Preclinical studies have demonstrated that a transplant of bone marrow-derived mesenchymal stem cells (MSCs) elicits paracrine effects resulting in anatomical repair and partial functional … Continue reading

Posted in Biomaterials, Chronic Spinal Cord Injury Research, Neuroscience Abstracts, spinal cord injury research, Stem Cell Research | Tagged , ,

From wheelchair to walking after spinal cord injury

Several paraplegics can now walk again – thanks to precise electrical stimulation of their spinal cords via a wireless implant and intensive neurorehabilitation. Speaking at Science Unlimited 2019, Grégoire Courtine illustrated this incredible spinal implant technology, as well as the … Continue reading

Posted in Biomaterials, Chronic Spinal Cord Injury Research, Neuromodulation, Rehabilitation, spinal cord injury research | Tagged

ReNetX Bio, Inc. Announces U.S. FDA Authorization to Proceed for IND Application to Treat Patients with Chronic Spinal Cord Injury

NEW HAVEN, Conn., June 19, 2019 /PRNewswire/ — ReNetX Bio, Inc., a leading biotechnology company committed to reversing disease and damage for patients suffering from central nervous system disorders, has announced that the U.S. Food and Drug Administration (FDA) has allowed the … Continue reading

Posted in Chronic Spinal Cord Injury Research, spinal cord injury research | Tagged | 2 Comments

Regeneration of Spinal Cord Connectivity Through Stem Cell Transplantation and Biomaterial Scaffolds

Authors: Hiroyuki Katoh, Kazuya Yokota and Michael Fehlings “In this review, we outline the pathophysiology of SCI that makes the spinal cord refractory to regeneration and discuss the research that has been done with cell replacement and biomaterial implantation strategies, … Continue reading

Posted in Biomaterials, Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged , , | 1 Comment