Category Archives: spinal cord injury research

An integrated in silico pipeline identifies a novel TF combination that promotes enhanced CST growth following injury

Authors *I. VENKATESH1, Z. WANG2, V. MEHRA1, E. EASTWOOD1, M. SIMPSON1, A. CHAKRABORTY1, D. GROSS1, Z.BEINE1, M. CABAHUG1, G. OLSON1, M. G. BLACKMORE3;2Dept. of Biomed. Sci., 3Biomed. Sci., 1Marquette Univ., Milwaukee, WI Lab Abstract Embryonic and peripheral neurons respond to … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, spinal cord injury research | Tagged , , | 1 Comment

Spike timing-dependent plasticity in the adult rat with chronic cervical spinal cord contusion

Authors: *N. DE LA OLIVA1, A. E. HAGGERTY1, M. A. PEREZ1,2, M. OUDEGA1,2,3,4; 1 Miami Project To Cure Paralysis, Univ. of Miami, Miami, FL; 2 Bruce W. Carter Dept. of Veterans Affairs Med. Ctr., Miami, FL; 3 Affiliated Cancer Hosp. … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuromodulation, Neuroscience Abstracts, Rehabilitation, spinal cord injury research | 1 Comment

Effect of PTEN antagonist peptide on the functional motor recovery in rat

Authors: *S. LV1, W. WU2; 1 Guangdong-hongkong-Macau Inst. of CNS Regeneration, Guangzhou, China; 2 The Univ.Of Hong Kong, Hong Kong SAR, Hong Kong Lab Abstract: Ventral root injury results in great loss of motor functions because of the inefficient axon … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research | 1 Comment

GDF10 promotes axonal regeneration and functional recovery: A novel gene therapy strategy for spinal cord injury

Authors:*P. M. ABDUL-MUNEER, S. BHOWMICK, V. D’MELLO; Hackensack Meridian Hlth. JFK Med. Ctr., Edison, NJ Neuroscience 2019 LINK Lab Abstract: Spinal cord injury (SCI) occurs when there is damage from trauma, loss of normal blood supply, or a mass effect … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, spinal cord injury research, Stem Cell Research | Tagged , , | 1 Comment

GTX Medical and NeuroRecovery Technologies to merge

GTX Medical and NeuroRecovery Technologies today announced their merger into a global company for the development of neuromodulation therapies for spinal cord injuries. The two merging companies plan to develop the targeted epidural spine stimulation system, an implantable spinal cord … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuromodulation, Rehabilitation, spinal cord injury research | Tagged , | 3 Comments

Candidate Therapy From Quebec for Chronic SCI Being Developed in Parallel by Academics and Companies in Switzerland and the Netherlands

QUEBEC CITY, CANADA, October 10th 2019 – Today, Laboratoires Guertin announces that a campaign for funding has been launched to support a phase IIb-enabling pilot study with a tritherapy candidate (buspirone/L-DOPA/carbidopa)called Spinalon. This experimental oral pill has been shown to … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuromodulation, Rehabilitation, spinal cord injury research | Tagged | 6 Comments

Moving beyond the glial scar for spinal cord repair

Authors: Elizabeth J. Bradbury and Emily R. Burnside Abstract: Traumatic spinal cord injury results in severe and irreversible loss of function. The injury triggers a complex cascade of inflammatory and pathological processes, culminating in formation of a scar. While traditionally … Continue reading

Posted in Chronic Spinal Cord Injury Research, Regenerative Medicine, spinal cord injury research | Tagged , | 1 Comment

The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?

Author: James W. Fawcett Abstract: Axon regeneration in the CNS is inhibited by many extrinsic and intrinsic factors. Because these act in parallel, no single intervention has been sufficient to enable full regeneration of damaged axons in the adult mammalian … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Ligand, spinal cord injury research, Stem Cell Research | Tagged

The potential of electric field for promoting neurite guidance in spinal cord injury regeneration strategies

Authors*A. VARONE, Z. N. MUHAMAT, A. M. RAJNICEK, W. HUANG; Lab Abstract: Introduction Spinal cord injury, for which there is no cure, can lead to permanent loss of neurological function. Reasons for failed axon regrowth include poor intrinsic growth capacity … Continue reading

Posted in Chronic Spinal Cord Injury Research, spinal cord injury research | Tagged , , | 2 Comments

Extraction and selective activation of muscle synergies through spinal stimulation for SCI

Authors: *R. CHENG, J. W. BURDICK; Lab Abstract: Epidural spinal stimulation (ESS) has been shown to enable recovery of motor control in patients with clinically complete spinal cord injury (SCI). It is hypothesized that this results from activation of postural … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuromodulation, Neuroscience Abstracts, Rehabilitation, spinal cord injury research | Tagged , , | 2 Comments