Category Archives: Rehabilitation

Nick Terrafranca from NeuroRecovery Technologies

NeuroRecovery Technologies specializes in Spinal Cord Stimulation for spinal cord injury. Nick Terrafranca, CEO, describes the technology and an update on the progress of their research.

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Lumbosacral spinal cord epidural stimulation improves voiding function after human SCI

Authors: Herrity AN1,2, Williams CS3, Angeli CA1,4, Harkema SJ1,2,4, Hubscher CH5,6 Deficits in urologic function after spinal cord injury (SCI) manifest both as a failure to store and empty, greatly impacting daily life. While current management strategies are necessary for … Continue reading

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Task specific spinal cord epidural stimulation enables independent step cycles during BWST stepping in motor complete humans

Various studies in the animal model have shown recovery of stepping with spinal cord epidural stimulation following a spinal cord injury. Our group had shown that epidural stimulation of lumbosacral spinal cord, combined with activity based training, enabled four motor … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Rehabilitation, Spinal Research | 1 Comment

Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord.

Journal of Neural Engineering Abstract: OBJECTIVE: We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below … Continue reading

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A computational model of epidural electrical stimulation of the cervical spinal cord in non-human primates

Abstract: Cervical spinal cord injury alters the communication between the brain and the spinal circuits controlling movement, often leading to tetraplegia. Epidural Electrical Stimulation (EES) of the lumbar spinal cord has shown promising results to restore leg motor control after … Continue reading

Posted in Biomaterials, Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Rehabilitation, Spinal Research | 1 Comment

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

Abstract: Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement. Failure of these projections to reorganize leads to permanent paralysis. Here we modeled these injuries in rodents. A severe contusion abolished all motor cortex … Continue reading

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Serotonin receptor and dendritic plasticity in the spinal cord mediated by chronic serotonergic pharmacotherapy combined with exercise following complete SCI in the adult rat

Abstract: Severe spinal cord injury (SCI) damages descending motor and serotonin (5-HT) fiber projections leading to paralysis and serotonin depletion. 5-HT receptors (5-HTRs) subsequently upregulate following 5-HT fiber degeneration, and dendritic density decreases indicative of atrophy. 5-HT pharmacotherapy or exercise can improve locomotor behavior after … Continue reading

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Enabling hand function in chronic spinal cord injury patients with non-invasive transcutaneous stimulation and buspirone: A double-blinded, sham controlled pilot study

Spinal cord injury (SCI) is one of the leading causes of long term paralysis. For patients with a chronic SCI treatment options are limited. Physical therapy can help maintain general health but little to no functional improvement is expected after … Continue reading

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Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury

Abstract: Recovery from serious neurological injury requires substantial rewiring of neural circuits. Precisely-timed electrical stimulation could be used to restore corrective feedback mechanisms and promote adaptive plasticity after neurological insult, such as spinal cord injury (SCI) or stroke. This study … Continue reading

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Development of an intraneural peripheral stimulation paradigm for reversing hand paralysis in non-human primates

Regaining the capacity to grasp and manipulate objects is of crucial importance to people living with upper limb paralysis. Functional electrical stimulation of forearm muscles has been used to reanimate paralyzed muscles. However, complex setups requiring multiple muscles to be … Continue reading

Posted in Biomaterials, Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Rehabilitation, Spinal Research