Category Archives: Rehabilitation

Robotic platform maximizing gravity-dependent gait interactions to train standing and walking after neurological disorders

Gait recovery after neurological disorders requires re-mastering the interplay between body mechanics and gravitational forces. Despite the importance of gravity-dependent gait interactions for promoting this learning, this essential aspect of gait rehabilitation have received little attention. Here, we introduce a … Continue reading

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Mayo pushes forward with Neuromodulation Discoveries for SCI

Drs. Peter Grahn, Kendall Lee, Igor Lavrov, and Kristin Zhao, from Mayo Clinic in Rochester, MN, review the results of their study appearing in the April 2017 issue of Mayo Clinic Proceedings showing volitional movement, standing, and step-like actions via … Continue reading

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Gait rehabilitation enabled by epidural electrical stimulation of lumbar segments in a person with a chronic incomplete SCI

Various studies in animal models showed that robot-assisted gait rehabilitation enabled by epidural electrical stimulation of the lumbar spinal cord improves the recovery of leg motor control after spinal cord injury. Recent studies showed that this stimulation is also capable … Continue reading

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Rerouting cortical drive through residual spinal tissue mediates motor function recovery after severe SCI

A severe contusion of thoracic segments disrupts the motor-circuit communication matrix linking the brain and the spinal cord. Electrochemical stimulation applied over lumbar segments restored this communication, which enabled volitional control of leg movements in rodents and humans with motor … Continue reading

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What Budget Cuts Might Mean for US Science

A look at the historical effects of downsized research funding suggests that the Trump administration’s proposed budget could hit early-career scientists the hardest. By Diana Kwon | March 21, 2017 The Trump administration’s proposed federal budget has already evoked significant … Continue reading

Posted in Chronic Spinal Cord Injury Research, Regenerative Medicine, Rehabilitation, Spinal Research

Noradrenergic pathways and epidural electrical stimulation synergistically modulate proprioceptive feedback circuits in order to restore locomotion after SCI

Abstract Several interventions exploiting chemical and electrical neuromodulation therapies have been designed to engage spinal sensorimotor circuits in order to facilitate the recovery of standing and walking after spinal cord injury. However, the mechanisms through which electrical and chemical stimulation … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Rehabilitation, Spinal Research

Assessment of the combined effects of chondroitinase and autologous Schwann cells on hand function after cervical SCI in primates

Abstract Introduction: Chondroitinase ABC and Schwann cells have been shown independently to promote functional recovery in rodents after contusive injury. Autologous human Schwann cells ahSC are being tested in Phase 1 clinical trials for sub-acute and chronic SCI. Recognizing the … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, Rehabilitation, Spinal Research, Stem Cell Research

Selective late I-wave stimulation enhances voluntary motor output after SCI

Abstract Targeted stimulation of the corticospinal tract has been shown to improve voluntary motor output in humans with spinal cord injury (SCI; Bunday and Perez, 2012). Here, we used a novel protocol that targeted late synaptic inputs into corticospinal neurons … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Rehabilitation, Spinal Research

Restoring Bladder, Bowel and Sexual Function after SCI – Berkeley Spinal Network

Presenter: Graham Creasey, MD, Professor of Spinal Cord Injury Medicine, Stanford University Dr. Creasey discusses a pacemaker developed in Britain that is capable of producing an erection as well as emptying the bladder and bowel, reducing infection and the use … Continue reading

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Improvements in bladder, bowel and sexual outcomes following task specific training in human SCI

Abstract The loss of urogenital and bowel functions are some of the most important sequalae as a result of spinal cord injury (SCI). In an upper motor neuron (UMN) injury, a neurogenic bladder may manifest as a failure to store, … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Rehabilitation, Spinal Research