Tag Archives: Dr. Murray Blackmore

Combined expression of pro-regenerative transcription factors and transplanted stem cells to promote corticospinal tract regeneration.

The failure of axon regeneration in the injured spinal cord results in partial or complete loss of function distal to the injury. To restore the function, severed axons must regrow and functionally reconnect to appropriate targets below the injury site. … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, Regenerative Medicine, Spinal Research, Stem Cell Research | Tagged , , | Leave a comment

Overexpression of KLF6 in corticospinal tract neurons promotes axon growth after spinal injury

Axonal regeneration in the central nervous system is limited in part by a developmental decline in the intrinsic regenerative capacity of central nervous system (CNS) neurons. Changes in gene expression are likely involved, and thus transcription factors that orchestrate gene … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, Spinal Research, Stem Cell Research | Tagged , , | 2 Comments

Could Cancer Genes Help Repair Spinal Cord Injuries?

A Marquette University researcher hopes his work could be a promising step towards a cure for spinal cord injuries. Dr. Murray Blackmore turned to an unlikely ally in his work – cancer genes. Current medical practices cannot heal a spinal … Continue reading

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COMBINED GENETIC/EPIGENETIC MANIPULATIONS TO PROMOTE CST AXON REGENERATION

Combined genetic/epigenetic manipulations to promote CST axon regeneration Embryonic neurons and peripheral neurons respond to axon injury with activation of transcriptional programs conducive to regrowth. In contrast, mature CNS neurons fail to reactivate expression of crucial regeneration associated genes (RAGs) … Continue reading

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OPTOGENETIC EVALUATION OF FUNCTIONAL SYNAPTIC RECONNECTION BY CORTICOSPINAL TRACT AXONS IN THE INJURED SPINAL CORD

OPTOGENETIC EVALUATION OF FUNCTIONAL SYNAPTIC RECONNECTION BY CORTICOSPINAL TRACT AXONS IN THE INJURED SPINAL CORD Spinal cord injury results in partial or complete loss of neural communication across the site of injury. To restore function, axons must extend into denervated … Continue reading

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Combinatorial testing of transcriptional modification and chondroitinase treatment to promote axon regeneration and functional recovery after spinal cord injury

Society for Neuroscience Chicago 2015 Poster 226. Spinal Cord Injury: Restorative Strategies Location: Hall A Time: Sunday, October 18, 2015, 1:00 PM – 5:00 PM Program#/Poster#: 226.25/H35 Topic: C.10. Trauma Support: NIH Grant NS083983-01 The International Spinal Research Trust Title: … Continue reading

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Epigenetic profiling reveals a developmental decrease in promoter accessibility of regeneration associated genes in CNS neurons

Society for Neuroscience Chicago 2015 Central Nervous System Regeneration Transplantation and Regeneration Support: The Bryon Riesch foundation SCIS/U2FP Unite 2 Fight Paralysis Title: Epigenetic profiling reveals a developmental decrease in promoter accessibility of regeneration associated genes in CNS neurons Authors: … Continue reading

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Optogenetic evaluation of functional synaptic reconnection by corticospinal tract axons in the injured spinal cord

Society for Neuroscience Chicago 2015 Spinal Cord Injury: Restorative Strategies Support: NIH Grant NS083983-01 International Spinal Research Trust Title: Optogenetic evaluation of functional synaptic reconnection by corticospinal tract axons in the injured spinal cord Authors: *N. JAYAPRAKASH, B. HOEYNCK, N. … Continue reading

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The tumor suppressor HHEX restricts axon growth in central nervous system neurons

Society for Neuroscience Chicago 2015 Poster 568. Central Nervous System Regeneration Location: Hall A Time: Tuesday, October 20, 2015, 1:00 PM – 5:00 PM Program#/Poster#: 568.12/A55 Topic: A.07. Transplantation and Regeneration Support: The Bryon Riesch Paralysis Foundation SCIS/Unite 2 Fight … Continue reading

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Dr. Murray Blackmore: The tumor suppressor HHEX inhibits axon growth …

For those watching the gene discovery work in the Blackmore lab at Marquette University, this is good news. Last year, Dr. Blackmore told us about the screening work being done in his lab. Here is the abstract for the publication … Continue reading

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