Tag Archives: Marquette University

Combined expression of pro-regenerative transcription factors and transplanted stem cells to promote corticospinal tract regeneration.

The failure of axon regeneration in the injured spinal cord results in partial or complete loss of function distal to the injury. To restore the function, severed axons must regrow and functionally reconnect to appropriate targets below the injury site. … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, Regenerative Medicine, Spinal Research, Stem Cell Research | Tagged , ,

Overexpression of KLF6 in corticospinal tract neurons promotes axon growth after spinal injury

Axonal regeneration in the central nervous system is limited in part by a developmental decline in the intrinsic regenerative capacity of central nervous system (CNS) neurons. Changes in gene expression are likely involved, and thus transcription factors that orchestrate gene … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, Spinal Research, Stem Cell Research | Tagged , , | 2 Comments

Could Cancer Genes Help Repair Spinal Cord Injuries?

A Marquette University researcher hopes his work could be a promising step towards a cure for spinal cord injuries. Dr. Murray Blackmore turned to an unlikely ally in his work – cancer genes. Current medical practices cannot heal a spinal … Continue reading

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COMBINED GENETIC/EPIGENETIC MANIPULATIONS TO PROMOTE CST AXON REGENERATION

Combined genetic/epigenetic manipulations to promote CST axon regeneration Embryonic neurons and peripheral neurons respond to axon injury with activation of transcriptional programs conducive to regrowth. In contrast, mature CNS neurons fail to reactivate expression of crucial regeneration associated genes (RAGs) … Continue reading

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OPTOGENETIC EVALUATION OF FUNCTIONAL SYNAPTIC RECONNECTION BY CORTICOSPINAL TRACT AXONS IN THE INJURED SPINAL CORD

OPTOGENETIC EVALUATION OF FUNCTIONAL SYNAPTIC RECONNECTION BY CORTICOSPINAL TRACT AXONS IN THE INJURED SPINAL CORD Spinal cord injury results in partial or complete loss of neural communication across the site of injury. To restore function, axons must extend into denervated … Continue reading

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Epigenetic profiling reveals a developmental decrease in promoter accessibility of regeneration associated genes in CNS neurons

Society for Neuroscience Chicago 2015 Central Nervous System Regeneration Transplantation and Regeneration Support: The Bryon Riesch foundation SCIS/U2FP Unite 2 Fight Paralysis Title: Epigenetic profiling reveals a developmental decrease in promoter accessibility of regeneration associated genes in CNS neurons Authors: … Continue reading

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Optogenetic evaluation of functional synaptic reconnection by corticospinal tract axons in the injured spinal cord

Society for Neuroscience Chicago 2015 Spinal Cord Injury: Restorative Strategies Support: NIH Grant NS083983-01 International Spinal Research Trust Title: Optogenetic evaluation of functional synaptic reconnection by corticospinal tract axons in the injured spinal cord Authors: *N. JAYAPRAKASH, B. HOEYNCK, N. … Continue reading

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Dr. Murray Blackmore: The tumor suppressor HHEX inhibits axon growth …

For those watching the gene discovery work in the Blackmore lab at Marquette University, this is good news. Last year, Dr. Blackmore told us about the screening work being done in his lab. Here is the abstract for the publication … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, Spinal Research, Stem Cell Research | Tagged ,

The SmartBox and Optogenetics work at the Blackmore Lab for SCI

Drs. Murray Blackmore and Naveen Jayaprakash tell us about their experiences with the SmartBox. In their efforts to find a cure for spinal cord injury, the Blackmore Lab utilizes an optogenetic approach to study axonal growth in the spinal cords … Continue reading

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Dr. Murray Blackmore’s SCI research lab now bolstered with 1.6 Million NIH grant

Dr. Murray Blackmore recently had his research lab bolstered with seed grants and gifts that have led to a 1.6 million dollar grant from the National Institute of Health. The grant will fund continued research into gene therapy reagents and … Continue reading

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