Tag Archives: Marquette University

An integrated in silico pipeline identifies a novel TF combination that promotes enhanced CST growth following injury

Authors *I. VENKATESH1, Z. WANG2, V. MEHRA1, E. EASTWOOD1, M. SIMPSON1, A. CHAKRABORTY1, D. GROSS1, Z.BEINE1, M. CABAHUG1, G. OLSON1, M. G. BLACKMORE3;2Dept. of Biomed. Sci., 3Biomed. Sci., 1Marquette Univ., Milwaukee, WI Lab Abstract Embryonic and peripheral neurons respond to … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, spinal cord injury research | Tagged , , | 1 Comment

Marquette receives $500,000 for research from the Bryon Riesch Foundation

The Bryon Riesch Paralysis Foundation pledged Feb. 15 to donate $500,000 to Marquette’s College of Health Sciences to fund research, particularly that of Murray Blackmore, an associate professor of biomedical sciences. Blackmore’s lab studies spinal cord injuries, but more specifically studies gene … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, spinal cord injury research | Tagged , ,

Marquette professor awarded $1.6 million NIH grant for spinal cord injury research

Marquette University professor Murray Blackmore was awarded a $1.6 million grant from the National Institutes of Health to continue his research of spinal cord injury and paralysis. Dr. Murray Blackmore, associate professor of biomedical sciences in the College of Health … Continue reading

Posted in Chronic Spinal Cord Injury Research, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged ,

Combined expression of pro-regenerative transcription factors and transplanted stem cells to promote corticospinal tract regeneration.

The failure of axon regeneration in the injured spinal cord results in partial or complete loss of function distal to the injury. To restore the function, severed axons must regrow and functionally reconnect to appropriate targets below the injury site. … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged , ,

Overexpression of KLF6 in corticospinal tract neurons promotes axon growth after spinal injury

Axonal regeneration in the central nervous system is limited in part by a developmental decline in the intrinsic regenerative capacity of central nervous system (CNS) neurons. Changes in gene expression are likely involved, and thus transcription factors that orchestrate gene … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged , , | 3 Comments

Could Cancer Genes Help Repair Spinal Cord Injuries?

A Marquette University researcher hopes his work could be a promising step towards a cure for spinal cord injuries. Dr. Murray Blackmore turned to an unlikely ally in his work – cancer genes. Current medical practices cannot heal a spinal … Continue reading

Posted in Chronic Spinal Cord Injury Research, Gene Therapy, Regenerative Medicine, spinal cord injury research | Tagged , ,

COMBINED GENETIC/EPIGENETIC MANIPULATIONS TO PROMOTE CST AXON REGENERATION

Combined genetic/epigenetic manipulations to promote CST axon regeneration Embryonic neurons and peripheral neurons respond to axon injury with activation of transcriptional programs conducive to regrowth. In contrast, mature CNS neurons fail to reactivate expression of crucial regeneration associated genes (RAGs) … Continue reading

Posted in Neuroscience Abstracts, spinal cord injury research | Tagged , ,

OPTOGENETIC EVALUATION OF FUNCTIONAL SYNAPTIC RECONNECTION BY CORTICOSPINAL TRACT AXONS IN THE INJURED SPINAL CORD

OPTOGENETIC EVALUATION OF FUNCTIONAL SYNAPTIC RECONNECTION BY CORTICOSPINAL TRACT AXONS IN THE INJURED SPINAL CORD Spinal cord injury results in partial or complete loss of neural communication across the site of injury. To restore function, axons must extend into denervated … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research | Tagged , ,

Epigenetic profiling reveals a developmental decrease in promoter accessibility of regeneration associated genes in CNS neurons

Society for Neuroscience Chicago 2015 Central Nervous System Regeneration Transplantation and Regeneration Support: The Bryon Riesch foundation SCIS/U2FP Unite 2 Fight Paralysis Title: Epigenetic profiling reveals a developmental decrease in promoter accessibility of regeneration associated genes in CNS neurons Authors: … Continue reading

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Optogenetic evaluation of functional synaptic reconnection by corticospinal tract axons in the injured spinal cord

Society for Neuroscience Chicago 2015 Spinal Cord Injury: Restorative Strategies Support: NIH Grant NS083983-01 International Spinal Research Trust Title: Optogenetic evaluation of functional synaptic reconnection by corticospinal tract axons in the injured spinal cord Authors: *N. JAYAPRAKASH, B. HOEYNCK, N. … Continue reading

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