Tag Archives: Dr. Mark Tuszynski

Calcium imaging of synaptic connectivity between host and neural progenitor cell graft-derived neurons after spinal cord injury

Posted on January 13, 2019 by christalpowell

Authors: STEVEN L. CETO, K. SEKIGUCHI, A. NIMMERJAHN, M. H. TUSZYNSKI; Lab Abstract: Neural stem cells (NSCs) grafted into sites of spinal cord injury (SCI) may act as new electrophysiological relays between host neurons above and below the lesion. Host … Continue reading →

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged , | Comments Off on Calcium imaging of synaptic connectivity between host and neural progenitor cell graft-derived neurons after spinal cord injury

Continued development of human neural stem cell grafts into non-human primate spinal cord contusion or hemisection lesions

Posted on December 16, 2018 by christalpowell

Authors: *E. S. ROSENZWEIG, J. H. BROCK, P. LU, H. KUMAMARU, J. L. WEBER, C. A. WEINHOLTZ, R. MOSEANKO, S. HAWBECKER, R. PENDER, C. L. CRUZEN, E. A. SALEGIO,, J. HUIE, C. ALMEIDA, Y. S. NOUT-LOMAS, L. A. HAVTON, A. … Continue reading →

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, spinal cord injury research, Stem Cell Research | Tagged , | Comments Off on Continued development of human neural stem cell grafts into non-human primate spinal cord contusion or hemisection lesions

Stem cell lab work continues to show progress

Posted on August 8, 2018 by christalpowell

Even though we may be years away from a robust stem cell treatment coming to the market for spinal cord injury, the lab work continues to progress and show great promise.  What we don’t know is; which stem cell will … Continue reading →

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In a Break with Dogma, Myelin Boosts Neuron Growth in Spinal Cord Injuries

Posted on July 6, 2018 by christalpowell

The molecule inhibits adult axon regeneration, but appears to stimulate young neurons by Scott LaFee Recovery after severe spinal cord injury is notoriously fraught, with permanent paralysis often the result. In recent years, researchers have increasingly turned to stem cell-based … Continue reading →

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Synaptic connectivity between host and neural progenitor cell-derived neurons after spinal cord injury

Posted on May 7, 2018 by christalpowell

Neural stem cells (NSCs) grafted into sites of spinal cord injury (SCI) may act as new electrophysiological relays between host neurons above and below the lesion. Host axons regenerate robustly into NSC grafts and form synapses; in turn, graft axons … Continue reading →

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Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury

Posted on March 18, 2018 by christalpowell

Lab Abstract: Inhibitory chondroitin sulfate proteoglycans (CSPGs) in the extracellular matrix hinder axonal regeneration after spinal cord injury (SCI). In particular, CSPGs form ‘peri-neuronal nets’ that may limit axonal regrowth and synaptic plasticity. Moreover, CSPGs are newly synthesized at sites … Continue reading →

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Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts

Posted on January 27, 2018 by christalpowell

Neural progenitor cell (NPC) transplantation has high therapeutic potential in neurological disorders. Functional restoration may depend on the formation of reciprocal connections between host and graft. While it has been reported that axons extending out of neural grafts in the … Continue reading →

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It’s Not a Rat’s Race for Human Stem Cells Grafted to Repair Spinal Cord Injuries

Posted on September 2, 2017 by christalpowell

By Scott LaFee Lengthy study finds that implanted neural stem cells grow slow and steady, and success needs to be measured accordingly More than one-and-a-half years after implantation, researchers at University of California San Diego School of Medicine and the … Continue reading →

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Stem Cells Used to Successfully Regenerate Damage in Corticospinal Injury

Posted on March 29, 2016 by christalpowell

For first time, researchers show functional benefit in animal model of key motor control system called the corticospinal tract. Source Newsroom: University of California, San Diego Health .Newswise — Writing in the March 28 issue of Nature Medicine, researchers at … Continue reading →

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De-novo myelination of grafted neural progenitor cells in the adult CNS

Posted on March 6, 2016 by christalpowell

We previously reported that neural progenitor cells (NPCs) grafted into sites of spinal cord injury (SCI) exhibit extensive axonal outgrowth and formation of new synaptic connections with host neurons, forming novel functional neural relays across lesion sites. In the present … Continue reading →

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