Tag Archives: Dr. Jerry Silver

Case Western Reserve Researchers Restore Breathing and Partial Forelimb Function in Rats with Chronic Spinal Cord Injuries

Promising results provide hope for humans suffering from chronic paralysis “Millions of people worldwide are living with chronic spinal cord injuries, with 250,000 to 500,000 new cases each year—most from vehicle crashes or falls. The most severe spinal cord injuries … Continue reading

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Worldwide licensing agreement made on peptide developed in Silver laboratory at Case Western Reserve University

Read the Full Article at Globe Newswire.   VANCOUVER, British Columbia, July 18, 2018 (GLOBE NEWSWIRE) — NervGen Pharma Corp. (“NervGen”), in Vancouver, and Case Western Reserve University (“Case Western Reserve”) in Cleveland have entered into an exclusive worldwide licensing agreement to research, develop and … Continue reading

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Modulation of Receptor Protein Tyrosine Phosphatase Sigma Increases Chondroitin Sulfate Proteoglycan Degradation through Cathepsin B Secretion to Enhance Axon Outgrowth

Authors: Amanda Phuong Tran, Sapna Sundar, Meigen Yu, Bradley T. Lang and Jerry Silver Abstract: Severed axon tips reform growth cones following spinal cord injury that fail to regenerate, in part, because they become embedded within an inhibitory extracellular matrix. … Continue reading

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Rapid and robust recovery of breathing 1.5 years after cervical spinal cord injury

Methods to restore respiratory function following chronic cervical spinal cord injury (SCI) have not been extensively studied. This represents a major gap in our current understanding as the primary cause of morbidity and mortality following cervical SCI is respiratory motor … Continue reading

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Dr. Jerry Silver: Latest chronic SCI research results featured at Cleveland FES Neural Prosthesis Seminar

The Silver SCI research lab is dedicated to repairing the chronically injured spinal cord and restoring function after paralysis. The presentation at the Cleveland FES Centers Neural Prosthesis Seminar covers not only the remarkable robust recovery of bladder function but … Continue reading

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APPRAISAL AND RESTORATION OF RESPIRATORY FUNCTION FOLLOWING ACUTE AND CHRONIC SPINAL CORD TRAUMA

APPRAISAL AND RESTORATION OF RESPIRATORY FUNCTION FOLLOWING ACUTE AND CHRONIC SPINAL CORD TRAUMA Cervical spinal cord injury typically causes robust detrimental effects to respiratory motor function. We provide evidence demonstrating that these profound effects persist from acute to chronic time … Continue reading

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CONTROL OF DIAPHRAGM ACTIVITY AFTER SCI IN THE ABSENCE OF SUPRASPINAL INPUT: THE CONTRIBUTION OF INTERNEURONS

CONTROL OF DIAPHRAGM ACTIVITY AFTER SCI IN THE ABSENCE OF SUPRASPINAL INPUT: THE CONTRIBUTION OF INTERNEURONS Respiratory drive is relayed to phrenic motor neurons via bulbospinal projections. Spinal cord injury at or above cervical level 4 disrupts these descending projections … Continue reading

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OPTIMIZATION OF INTRACELLULAR SIGMA PEPTIDE AS A TREATMENT FOR SPINAL CORD INJURY

OPTIMIZATION OF INTRACELLULAR SIGMA PEPTIDE AS A TREATMENT FOR SPINAL CORD INJURY Regeneration and sprouting following spinal cord injury is curtailed by several processes, with the inhibitory chondroitin-sulfate proteoglycan (CSPG)-rich glial scar and peri-neuronal net being major impediments. We designed … Continue reading

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Enhanced regeneration and functional recovery after root avulsion by manipulation of proteoglycan receptor protein tyrosine phosphatase-σ

Society for Neuroscience 2015 Nanosymposium SCI Therapeutic Strategies Trauma Enhanced regeneration and functional recovery after root avulsion by manipulation of proteoglycan receptor protein tyrosine phosphatase-σ Abstract: Following root avulsion, spinal nerves are physically disconnected from the spinal cord. Severe motor … Continue reading

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Intravenous multipotent adult progenitor cell treatment decreases inflammation leading to functional recovery following spinal cord injury

Following spinal cord injury (SCI), immune-mediated secondary injury exacerbates the extent of permanent neurological deficits. We investigated the capacity of adult bone marrow-derived stem cells, which exhibit immunomodulatory properties, to alter inflammatory processes and promote recovery following SCI. In vitro, … Continue reading

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