Category Archives: Spinal Research

Therapeutic impact of grafted oligogenic-directly reprogrammed neural precursor cells and chondroitinase ABC for chronic spinal cord injury

Authors *S. NORI1, J.-E. AHLFORS2, M. KHAZAEI1, Y. LIU1, J. WANG1, T. FUEHRMANN3, M. M. PAKULSKA3, M. HETTIARATCHI3, P. POON3, M. S. SHOICHET3, M. G. FEHLINGS1,4; 1Div. of Genet. and Develop., Krembil Res. Inst., Toronto, ON, Canada; 2New World Labs., … Continue reading

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Long Term Neural Stem Cell Transplant to repair Spinal Cord Injury: neurogenesis, gliogenesis and axon persistence

Paul Lu, PhD, Associate Researcher, University of California, San Diego – School of Medicine My primary research focuses on gene therapy and neural stem cells for spinal cord injury. My early studies focus on ex vivo gene therapy with neurotrophic … Continue reading

Posted in Chronic Spinal Cord Injury Research, Regenerative Medicine, Spinal Research, Stem Cell Research | Tagged , | 2 Comments

Molecular controls over corticospinal motor neuron segmental targeting

Authors: *V. V. SAHNI1, S. SHNIDER1, D. JABAUDON2, J. SONG1, F. DING1, J. D. MACKLIS1; 1Stem Cell and Regenerative Biol. and Ctr. for Brain Sci., Harvard Univ., Cambridge, MA; 2Univ. of Geneva, Geneva, Switzerland The corticospinal system controls performance of … Continue reading

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Novel induction of neural-ectoderm and differentiation of neural progenitors from human iPSCs using pressure

Authors: Z. PAPPALARDO1,2, L. CASSEREAU2, *B. A. ADAMS2, B. DOWNEY2, J. LIM2; 1San Francisco State Univ., San Francisco, CA; 2Xcell Biosci. Inc., San Francisco, CA Induced pluripotent stem cells (iPSCs) can be used for autologous regenerative medicine to treat conditions … Continue reading

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Differentiation and single cell RNA sequencing of V2a interneurons from human pluripotent stem cells

Authors *J. BUTTS1, D. A. MCCREEDY2, J. A. MARTINEZ-VARGAS3, C. A. GIFFORD4, L. J. NOBLE-HAEUSSLEIN5, T. C. MCDEVITT4; 1Bioengineering, Gladstone Inst. of Cardiovasc. Dis., San Francisco, CA; 2Neurolog. Surgery, UCSF, San Francisco, CA; 3Univ. of California – Berkeley, Berkeley, CA; … Continue reading

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Dr. Paul J. Reier presents at Working 2 Walk 2017

This Working 2 Walk 2017 video was taken in Miami Florida. Dr. Reier explained how electrical stimulation to activate silent neural circuits could be used to enhance spinal cord repair. Dr. Reier’s research addresses spinal cord injury (SCI) and repair with … Continue reading

Posted in Chronic Spinal Cord Injury Research, Rehabilitation, Spinal Research, Unite 2 Fight Paralysis, Working 2 Walk Science & Advocacy Symposium | Tagged , , , | Leave a comment

Partnership Hopes to Bring Breakthrough Epidural Stimulator Technologies to Millions

Inspired by the results of the first trial and the possibility of two very significant neuromodulation methods, the Foundation was motivated to accelerate its work. The prize of completing its mission and finding cures for spinal cord injury now seemed … Continue reading

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Fortuna Fix Announces Series B Financing, Adding Amgen Ventures and Macnguyen Family Office as Shareholders

(Newswire.com) Press Release: November 8, 2017 Fortuna Fix – Fortuna Fix (“Fortuna”), a private, clinical-stage Regenerative Medicine company is aiming to be the first to bring to the clinic a patient’s own neural stem cells (autologous) produced by direct reprogramming … Continue reading

Posted in Biomaterials, Chronic Spinal Cord Injury Research, Regenerative Medicine, Spinal Research, Stem Cell Research | Tagged ,

Targeting improvements in bladder function with epidural stimulation after human SCI

Abstract Deficits in urological function after spinal cord injury (SCI) include neurogenic detrusor overactivity and uncoordinated bladder and external urethral sphincter contractions, resulting in inefficient emptying and high intravesical pressure. Urinary retention and an inability of the bladder to store … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Rehabilitation, Spinal Research | 2 Comments

Cellular mechanisms influencing corticospinal and sensory axonal regeneration into neural stem cell grafts after SCI

Abstract Injured corticospinal tract axons regenerate robustly into caudalized neural progenitor cell (NPC) grafts and form functional synaptic connections with graft-derived neurons. However, the developmental fate of grafted NPCs, and whether those differentiated graft-derived neural subtypes might influence the regeneration … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, Rehabilitation, Spinal Research, Stem Cell Research