Category Archives: Spinal Research

Assessment of the combined effects of chondroitinase and autologous Schwann cells on hand function after cervical SCI in primates

Abstract Introduction: Chondroitinase ABC and Schwann cells have been shown independently to promote functional recovery in rodents after contusive injury. Autologous human Schwann cells ahSC are being tested in Phase 1 clinical trials for sub-acute and chronic SCI. Recognizing the … Continue reading

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Selective late I-wave stimulation enhances voluntary motor output after SCI

Abstract Targeted stimulation of the corticospinal tract has been shown to improve voluntary motor output in humans with spinal cord injury (SCI; Bunday and Perez, 2012). Here, we used a novel protocol that targeted late synaptic inputs into corticospinal neurons … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Rehabilitation, Spinal Research | 1 Comment

Restoring Bladder, Bowel and Sexual Function after SCI – Berkeley Spinal Network

Presenter: Graham Creasey, MD, Professor of Spinal Cord Injury Medicine, Stanford University Dr. Creasey discusses a pacemaker developed in Britain that is capable of producing an erection as well as emptying the bladder and bowel, reducing infection and the use … Continue reading

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Improvements in bladder, bowel and sexual outcomes following task specific training in human SCI

Abstract The loss of urogenital and bowel functions are some of the most important sequalae as a result of spinal cord injury (SCI). In an upper motor neuron (UMN) injury, a neurogenic bladder may manifest as a failure to store, … Continue reading

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Parameters of multi muscle neuromuscular stimulation: Effect on Muscle Volume

Abstract Acute spinal cord injury often leads to rapid muscle atrophy in the paralyzed limbs. Recently, we have shown that an intense novel form of standardized multi-muscle neuromuscular electrical stimulation (NMES) combined with dynamic standing retraining tasks may potentially restore … Continue reading

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Lower limb electrical stimulation alters trunk stability in individuals with spinal cord injury

Abstract Loss of movement ability below the level of injury is often a consequence of spinal cord injury (SCI). Subsequently, the associated rapid muscle atrophy after the injury may negatively affect overall functional recovery. Previously, our data have shown that … Continue reading

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Comparative transcriptomic analysis of sprouting and regenerating corticospinal neurons

Abstract The corticospinal tract (CST) is a critical motor system in humans for voluntary movement. The inability of adult corticospinal axons to spontaneously regenerate after spinal cord injury (SCI) may be attributable in part to incomplete activation of neuronal growth … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, Spinal Research

Working 2 Walk Panel Discussion with Carrie Shogren and Nick Terrafranca

The Working 2 Walk audience asks questions about the presentations given by Ms. Shogren and Dr. Terrafranca.

Posted in Chronic Spinal Cord Injury Research, Rehabilitation, Spinal Research, Unite 2 Fight Paralysis, Working 2 Walk Science & Advocacy Symposium | Tagged ,

LPA pathway modulates intrinsic axon growth of intact CNS neurons after spinal cord injury

Abstract Neurons in the adult central nervous system (CNS) are unable to regenerate after spinal cord injury (SCI) due to an inhibitory environment and a decreased intrinsic growth capacity. Modulating environmental inhibitors and their neuronal receptors such as Nogo Receptor … Continue reading

Posted in Neuroscience Abstracts, Spinal Research | 1 Comment

Short and long term effects of neural progenitor transplantation following cervical spinal cord contusion injury

Video and Abstract: Impaired breathing is a devastating consequence of cervical spinal cord injury (SCI) that increases morbidity and the risk of mortality. Injuries at high-to-mid cervical levels (C1-4) result in the most severe deficits as the phrenic motor circuitry … Continue reading

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