Category Archives: Spinal Research

Identification of Intrinsic Axon Growth Modulators for Intact CNS Neurons after Injury

Kathren L. Fink, Francesc López-Giráldez, In-Jung Kim, Stephen M. Strittmatter, William B.J. Cafferty Open Access DOI: http://dx.doi.org/10.1016/j.celrep.2017.02.058 Highlights •Mechanisms driving functional plasticity of intact CNS circuits are unknown •Retrograde spinal tracing reveals CST neurons undergoing functional plasticity •Transcriptional profiling of … Continue reading

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What Budget Cuts Might Mean for US Science

A look at the historical effects of downsized research funding suggests that the Trump administration’s proposed budget could hit early-career scientists the hardest. By Diana Kwon | March 21, 2017 The Trump administration’s proposed federal budget has already evoked significant … Continue reading

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CITC LTD and partners on personalized stem cell therapies for injury and diseases of the CNS

CITC Ltd has recently concluded a non-esclusive license agreement with Provendis GmbH, a technology transfer agency of 27 universities of North Rhine-Westphalia, including the University of Bonn, for a manufacturing technology of autologous induced neural stem cells (iNSC) from adult … Continue reading

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Nerve growth At The Extremeties

Researchers have found a genetic signature located exclusively in the nerve cells that supply, or innervate, the muscles of an organism’s outermost extremities: the hands and feet. This signature, observed in both mice and chicks, involves the coordinated activity of … Continue reading

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Noradrenergic pathways and epidural electrical stimulation synergistically modulate proprioceptive feedback circuits in order to restore locomotion after SCI

Abstract Several interventions exploiting chemical and electrical neuromodulation therapies have been designed to engage spinal sensorimotor circuits in order to facilitate the recovery of standing and walking after spinal cord injury. However, the mechanisms through which electrical and chemical stimulation … Continue reading

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Paul Knoepfler Stem Blog “The Niche” providing weekly Q & A.

The Niche LINK: Segment 1. Where is the stem cell field now and where the heck is it heading? There are hundreds of questions. Readers often email me questions or leave them as comments. It’s not unusual to get questions … Continue reading

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Electrical neuromodulation of the cervical spinal cord facilitates forelimb skilled function recovery in spinal cord injured rats

Abstract: Enabling motor control by epidural electrical stimulation of the spinal cord is a promising therapeutic technique for the recovery of motor function after a spinal cord injury (SCI). Although epidural electrical stimulation has resulted in improvement in hindlimb motor … Continue reading

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Assessment of the combined effects of chondroitinase and autologous Schwann cells on hand function after cervical SCI in primates

Abstract Introduction: Chondroitinase ABC and Schwann cells have been shown independently to promote functional recovery in rodents after contusive injury. Autologous human Schwann cells ahSC are being tested in Phase 1 clinical trials for sub-acute and chronic SCI. Recognizing the … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Regenerative Medicine, Rehabilitation, Spinal Research, Stem Cell Research

Selective late I-wave stimulation enhances voluntary motor output after SCI

Abstract Targeted stimulation of the corticospinal tract has been shown to improve voluntary motor output in humans with spinal cord injury (SCI; Bunday and Perez, 2012). Here, we used a novel protocol that targeted late synaptic inputs into corticospinal neurons … Continue reading

Posted in Chronic Spinal Cord Injury Research, Neuroscience Abstracts, Rehabilitation, Spinal Research

Restoring Bladder, Bowel and Sexual Function after SCI – Berkeley Spinal Network

Presenter: Graham Creasey, MD, Professor of Spinal Cord Injury Medicine, Stanford University Dr. Creasey discusses a pacemaker developed in Britain that is capable of producing an erection as well as emptying the bladder and bowel, reducing infection and the use … Continue reading

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