Moving beyond the glial scar for spinal cord repair

Authors: Elizabeth J. Bradbury and Emily R. Burnside
Abstract: Traumatic spinal cord injury results in severe and irreversible loss of function. The injury triggers a complex cascade of inflammatory and pathological processes, culminating in formation of a scar. While traditionally referred to as a glial scar, the spinal injury scar in fact comprises multiple cellular and extracellular components. This multidimensional nature should be considered when aiming to understand the role of scarring in limiting tissue repair and recovery. In this Review we discuss recent advances in understanding the composition and phenotypic characteristics of the spinal injury scar, the oversimplification of defining the scar in binary terms as good or bad, and the development of therapeutic approaches to target scar components to enable improved functional outcome after spinal cord injury.

Emily Burnside

Dr. Elizabeth Bradbury

Read the FULL ARTICLE at Nature Communications Volume 10, Article number: 3879 (2019)

This entry was posted in Chronic Spinal Cord Injury Research, Regenerative Medicine, spinal cord injury research and tagged , . Bookmark the permalink.

1 Response to Moving beyond the glial scar for spinal cord repair

  1. daddyg303 says:

    I am a full time caregiver for my 75yo mom. She had her SCI in January of 2015. Your information is appreciated and gives us hope. Thank you to your staff and all those in the world doing this great work to help those with SCI. God Bless you all.
    Glen Jones, Aurora CO

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