Perspectives on “the biology of spinal cord regeneration success and failure”

Neural Regeneration Research Journal
Authors: Philippa Mary Warren, Amanda Phuong Tran, and Jerry Silver, Ph.D.

“In our recently co-authored Physiological Reviews manuscript entitled “The biology of regeneration failure and success after spinal cord injury” (Tran et al., 2018b), we sought to provide a comprehensive and up-to-date description of how the glial scar develops following spinal cord injury (SCI) to chronically inhibit axon regeneration. Our additional intention was to clarify some of the confusion in the field relating to an oversimplified view of the glial scar. We would like to take this opportunity to reiterate how the current body of literature, expounding details of the glial scar, has progressed beyond a simplified and outdated understanding of this structure as a mono-cellular arrangement consisting only of astrocytes that solely limit axon regeneration. Instead, our perception of the glial scar has evolved to acknowledge the nuances of this multi-cellular structure to one that is able to limit the expansion of inflammatory processes shortly following SCI and that also persists chronically to limit axon regeneration.”

See the Full Article at Neural Regeneration Research

Amanda Tran | Case Western Reserve University, Ohio | CWRU | Department of Neurosciences


Philippa Warren PhD, Kings College London, UK


The Biology of Regeneration Failure and Success After Spinal Cord Injury ABSTRACT

Tran, A. P., Warren, P. M., & Silver, J. (2018). The biology of regeneration failure and success after spinal cord injury. Physiological Reviews, 98(2), 881-917. DOI: 10.1152/physrev.00017.2017

(The Full Open Access Paper will be online April 1, 2019)

Advertisements
This entry was posted in Chronic Spinal Cord Injury Research, Regenerative Medicine, Spinal Research and tagged , , . Bookmark the permalink.

2 Responses to Perspectives on “the biology of spinal cord regeneration success and failure”

  1. Donna says:

    Hi, do you know if anyone in the UK are doing any trials? I am desperately seeking help for my tetraplegic son.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s