Neural Regeneration Research Journal
Authors: Philippa Mary Warren, Amanda Phuong Tran, and Jerry Silver, Ph.D.
“In our recently co-authored Physiological Reviews manuscript entitled “The biology of regeneration failure and success after spinal cord injury” (Tran et al., 2018b), we sought to provide a comprehensive and up-to-date description of how the glial scar develops following spinal cord injury (SCI) to chronically inhibit axon regeneration. Our additional intention was to clarify some of the confusion in the field relating to an oversimplified view of the glial scar. We would like to take this opportunity to reiterate how the current body of literature, expounding details of the glial scar, has progressed beyond a simplified and outdated understanding of this structure as a mono-cellular arrangement consisting only of astrocytes that solely limit axon regeneration. Instead, our perception of the glial scar has evolved to acknowledge the nuances of this multi-cellular structure to one that is able to limit the expansion of inflammatory processes shortly following SCI and that also persists chronically to limit axon regeneration.”
See the Full Article at Neural Regeneration Research
The Biology of Regeneration Failure and Success After Spinal Cord Injury ABSTRACT
Tran, A. P., Warren, P. M., & Silver, J. (2018). The biology of regeneration failure and success after spinal cord injury. Physiological Reviews, 98(2), 881-917. DOI: 10.1152/physrev.00017.2017
(The Full Open Access Paper will be online April 1, 2019)