One of the important strategies that labs have been focusing on for spinal cord injury has been how to best deal with CSPG (chondroitin sulfate proteoglycans) commonly known as the scar that builds up at the site of injury (lesion) and inhibits regeneration of axons. The article posted in Journal of Neurotrauma explains what they have found on possible treatments and important issues of where and when a treatment could be applied. This article from the Arthur Brown lab at Robarts Research Institute in Canada gives a nice summary of the work that has been completed and what scientists know from the hundreds of experiments performed that deal with the problem. They hope to harness a 2-fold potential of increased neuroplasticity and neuroprotection. (cp)
This work was supported by grants from the Canadian Institutes of Health Research (CIHR grant no. MOP 133460) and from the Rick Hansen Institute (G-2015-15).