Chondroitinase ABC (ChABC) treatment has been extensively used to demonstrate that the CS side chains of CSPGs are potent inhibitors of regeneration and plasticity in the extracellular matrix (ECM) of brain and spinal cord. We have sought for less invasive ways to enhance CNS regeneration and plasticity, which might be useful for the development of therapies for CNS traumas. To this end, we considered endogenously occurring molecules that might modulate functions of the CNS matrix in the juvenile brain which displays high plasticity in comparison to the adult brain.
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Paveliev, M. et al. HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix. Sci. Rep. 6, 33916; doi: 10.1038/srep33916 (2016).
Mikhail Paveliev, Keith K. Fenrich, Mikhail Kislin, Juha Kuja-Panula, Evgeny Kulesskiy, Markku Varjosalo, Tommi Kajander, Ekaterina Mugantseva, Anni Ahonen-Bishopp, Leonard Khiroug, Natalia Kulesskaya, Geneviève Rougon & Heikki Rauvala