Society for Neuroscience Chicago 2015
Poster 046. Spinal Cord Injury: Restorative Therapeutic Strategies Location: Hall A Time: Saturday, October 17, 2015, 1:00 PM – 5:00 PM Program#/Poster#: 46.04/D31
Topic: C.10. Trauma
Support: RGC GRF HKUST662011 RGC GRF HKUST16101414
Title: Pten deletion promotes regeneration of corticospinal tract axons one year after spinal cord injury
Authors: *K. LIU, S. ZHENG; HKUST, Kowloon, Hong Kong
Abstract: Chronic spinal cord injury (SCI) is a formidable hurdle that prevents a large number of injured axons from crossing the lesion, particularly the corticospinal tract (CST). This study shows that Pten deletion in the adult mouse cortex enhances compensatory sprouting of uninjured CST axons. Furthermore, forced upregulation of mTOR initiated either one month or one year after injury promoted regeneration of CST axons. Our results indicate that both developmental and injury-induced mTOR down-regulation in corticospinal motor neurons can be reversed in adults. Modulating neuronal mTOR activity is a potential strategy for axon regeneration after chronic SCI.
Disclosures: K. Liu: None. S. Zheng: None.