More than 20 years ago, Silver discovered that chondroitinase helps nerves reconnect. The enzyme is now entering dog clinical trials at Ames, Iowa and other universities.
But Silver has a new tool in his spinal cord regeneration toolkit. He’s developed a molecule, a peptide, that revs-up the regrowth of nerve cells.
Silver’s hopes are high for improving on the benefits of chondroitinase by itself. He says using just the enzyme alone doesn’t significantly improve the rats ability to walk, although they can urinate better. But he believes adding the peptide will “make them walk well and urinate really well!”
The peptide, developed by former grad student Brad Lang, worked surprisingly well in preliminary experiments.
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