Exploradio: Improving the lives of paralyzed people through research

Dr. Jerry Silver is a researcher at Case Western Reserve University. He was the first to discover that the enzyme chondroitinase allows nerves to regrow.

Dr. Jerry Silver is a researcher at Case Western Reserve University. He was the first to discover that the enzyme chondroitinase allows nerves to regrow. His latest discovery is a peptide that promises more profound nerve regeneration.

In this week’s Exploradio, WKSU’s Jeff St. Clair meets a Cleveland researcher who’s unlocking the secrets of how to repair a damaged spinal cord. Listen to this weeks radio interview about the research and plans going forward for the latest treatment paradigm with Bradley Lang, Amanda Tran and Dr. Jerry Silver.

More than 20 years ago, Silver discovered that chondroitinase helps nerves reconnect. The enzyme is now entering dog clinical trials at Ames, Iowa and other universities.

But Silver has a new tool in his spinal cord regeneration toolkit. He’s developed a molecule, a peptide, that revs-up the regrowth of nerve cells.

Silver’s hopes are high for improving on the benefits of chondroitinase by itself. He says using just the enzyme alone doesn’t significantly improve the rats ability to walk, although they can urinate better. But he believes adding the peptide will “make them walk well and urinate really well!”

The peptide, developed by former grad student Brad Lang, worked surprisingly well in preliminary experiments.

Read The Full Article HERE: and listen to the radio interview.

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