“Neuromodulatory Strategies for Recovery of Sensory-Motor Function after Severe Paralysis”: V. Reggie Edgerton, PhD, UCLA

reggie at W2WOne of the most anticipated speakers at the Working 2 Walk 2014 Symposium in Seattle Washington was Dr. V. Reggie Edgerton. With 40 years of experience in the field and the known successes with epidural stimulation coming to fruition the past few years, Unite 2 Fight Paralysis didn’t disappoint any attendees with arranging this engaging presentation!  A home run for sure!

2937cba Nick Terrafranca, CEO
In addition, U2FP was delighted to also have the CEO, Nick Terrafranca from the Southern California based start-up known as NeuroRecovery Technologies Inc. (Monarch Beach, CA) which is developing novel spinal-cord stimulator technology and holds the exclusive license to the IP related to it. Both Reggie and Nick were available to answer questions and explain the technology in addition to describing where the future on this technology is going.

I’ve arranged an interview for the coming months featuring Dr. Reggie Edgerton. I’ll post it here on the blog just as soon as it becomes available along with an update of all the information I’ve acquired.

Now, on with the W2W 2014 video presentation details with Dr. Reggie Edgerton…

It is well known that the sensory input representing the timing and level of loadbearing on the lower limbs is an important source of input to the central nervous system in sustaining postural and locomotor control. The degree to which this source of input is critical, however, continues to be not fully realized. Experiments will be described which demonstrate that after complete paralysis, the return of the experience of bipedal and quadrupedal loadbearing in response to lumbosacral stimulation can be used to restore standing after complete paralysis due to spinal cord injury in humans. Similar results have been achieved in rats, but in addition, full weight-bearing stepping can also be recovered in the presence of spinal epidural stimulation and pharmacological modulation largely involving serotonergic agonists. Finally we have observed that a progressive increase of the level of loadbearing on a daily basis in rats and humans further enhances the level of recovery of standing potential. The mechanisms of the recovery of motor function with these interventions are gradually being formulated from the perspective of how spinal networks can be fine-tuned to facilitate the performance of a wide range of complex motor tasks. This fine tuning can be accomplished using a combination of neuromodulatory interventions, including multiple forms of electrical stimulation, sensory modulation and pharmacological modulation. During the presentation, while the basic physiological concepts underlying the results outlined above are discussed, there will be an emphasis of the bioengineering advances that are needed to rapidly obtain a clinical presence that will result in significant levels of functional improvement following severe spinal cord injuries.

Without your valuable support of Unite 2 Fight Paralysis volunteers and your generous donations directed to the Working 2 Walk Video Library, the annual symposium video presentations could not be made possible for the paralysis community. Thank you for your generous support in supplying this educational material for research and advocacy to cure paralysis.

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