Extrinsic inhibitors in axon sprouting and functional recovery after SCI
- Jessica M Meves, Binhai Zheng Neurosciences Graduate Program, Department of Neurosciences, University of California San Diego, School of Med, 9500 Gilman Drive,MC 0691, LaJolla,CA Meves JM, Zheng B. Neural Regen Res 2014;9:460-1
The limited axonal growth after central nervous system (CNS) injury such as spinal cord injury presents a major challenge in promoting repair and recovery. The literature in axonal repair has focused mostly on frank regeneration of injured axons. Here, we argue that sprouting of uninjured axons, an innate repair mechanism of the CNS, might be more amenable to modulation in order to promote functional repair. Extrinsic inhibitors of axonal growth modulate axon sprouting after injury and may serve as the first group of therapeutic targets to promote functional repair…
Repairing the injured spinal cord: sprouting versus regeneration. Is this a realistic match?
Karim Fouad, Caitlin Hurd Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada Fouad K, Hurd C. Neural Regen Res 2014;9:462
The article by Meves and Zheng (2014) is addressing a continuous shift in the field of spinal cord injury (SCI) research that has occurred over the last century. Before that, the spinal cord was viewed as “hard wired” and treatment considerations were based on observations that axons in the periphery were able to regenerate, but those in the central nervous system (CNS) were not (David and Aguayo, 1981). This led to the suggestion that it is the CNS environment that inhibits neurite growth, which initiated a quest to identify the growth inhibitory factors in the CNS (Caroni et al., 1988). The ultimate goal was to neutralize these factors in order to enable regeneration of injured axons, potentially over long distances. More recently, however, the research focus has shifted to intrinsic factors such as PTEN gene deletion and transplantation of embryonic stem cells …